Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES008786-02
Application #
2749711
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1997-08-01
Project End
2002-07-31
Budget Start
1998-02-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Brown University
Department
Pathology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Luczak, Michal W; Zhitkovich, Anatoly (2018) Monoubiquitinated ?-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicol Appl Pharmacol 355:238-246
Krawic, Casey; Zhitkovich, Anatoly (2018) Toxicological Antagonism among Welding Fume Metals: Inactivation of Soluble Cr(VI) by Iron. Chem Res Toxicol 31:1172-1184
Krawic, Casey; Luczak, Michal W; Zhitkovich, Anatoly (2017) Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human Lungs. Chem Res Toxicol 30:1720-1729
Luczak, Michal W; Zhitkovich, Anatoly (2017) Nickel-induced HIF-1? promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells. Toxicol Appl Pharmacol 331:94-100
Luczak, Michal W; Green, Samantha E; Zhitkovich, Anatoly (2016) Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics. Environ Health Perspect 124:61-6
Sawant, Akshada; Kothandapani, Anbarasi; Zhitkovich, Anatoly et al. (2015) Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links. DNA Repair (Amst) 35:126-36
DeLoughery, Zachary; Luczak, Michal W; Ortega-Atienza, Sara et al. (2015) DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination. Toxicol Sci 143:54-63
DeLoughery, Zachary; Luczak, Michal W; Zhitkovich, Anatoly (2014) Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction. Chem Res Toxicol 27:843-51
Morse, Jessica L; Luczak, Michal W; Zhitkovich, Anatoly (2013) Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cells. Chem Res Toxicol 26:1591-8
Luczak, Michal W; Zhitkovich, Anatoly (2013) Role of direct reactivity with metals in chemoprotection by N-acetylcysteine against chromium(VI), cadmium(II), and cobalt(II). Free Radic Biol Med 65:262-269

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