Appalachian Kentuckians in Martin and Letcher Counties are grappling with a health-threatening drinking water crisis arising from exposures to disinfection by-products (DBPs). DBPs include compounds that have been associated with a variety of adverse health effects, including increased risk of bladder cancer and cardiovascular birth defects. This study, which builds on findings from two community-engaged NIEHS P30-funded pilot studies and one P30-funded community grant, uses a multi-method approach, stakeholder-engaged approach to reduce DBP exposures and improve public health in target counties.