The goal is the prevention or control of trachoma and other Chlamydia trachomatis infections of the eye. The goal is sought through better understanding of the pathogenesis, immunology and epidemiology of the infections, and through basic studies of the microorganisms.
The specific aims i nclude both clinical and laboratory studies. A long term clinical and laboratory follow-up of infants infected with C. trachomatis at birth is proposed to study the consequences of chronic infection. An exploratory study of eye infection with TWAR, an unusual chlamydia, will be undertaken. The laboratory studies will be directed at both applied diagnostic methods and more basic aspects of antigenicity, immunity and pathogenesis. They will use monoclonal antibodies and recombinant DNA techniques. Examples include: development of methods for direct staining to identify and type endemic trachoma organisms; simplification of immunotyping; antigenic analysis; production of anti-idiotypic monoclonal antibodies; application of purified antigens as vaccine; studies of neutralization of infectivity and toxicity; cloning of surface antigens and assessment of their biological role; and characterization of elementary body versus reticulate body DNA.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY000219-26
Application #
3255183
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1973-12-01
Project End
1991-11-30
Budget Start
1986-12-05
Budget End
1987-11-30
Support Year
26
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195