Abstract

Results of our previous studies in rabbits strongly indicate that immunologic mechanisms play an important role in the pathogenesis of recurrent uveitis caused by herpes simplex virus. The purpose of the proposed research projects is to carry out a further study on immunologic mechanisms of recurrent herpes simplex uveitis in rabbits and to define the role of T cells and B cells in the pathogenesis of the disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY000964-10S1
Application #
3255635
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1980-05-01
Project End
1986-01-31
Budget Start
1984-05-01
Budget End
1986-01-31
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Overall Medical
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Hatano, H; Oh, J O; Ou, K H et al. (1988) Induction of Fc and C3b receptors on rabbit corneal cells by herpes simplex virus. Invest Ophthalmol Vis Sci 29:1352-6
Friedlaender, R P; Oh, J O; Minasi, P et al. (1987) Protective effect of passive immunization on herpetic retinitis of newborn rabbits. Curr Eye Res 6:161-6
Hatano, H; Oh, J O (1987) Effect of neuraminidase on Fc and C3b receptors on rabbit corneal cells infected with herpes simplex virus. Curr Eye Res 6:53-7
Ohashi, Y; Oh, J O; Ou, K H et al. (1986) Role of virus-infected mononuclear leukocytes in herpetic chorioretinitis of newborn rabbits. Invest Ophthalmol Vis Sci 27:1459-65
Oh, J O (1986) Type 2 herpes simplex virus infections. Yonsei Med J 27:1-6
Oh, J O (1985) Immunology of viral infections. Int Ophthalmol Clin 25:107-16
Oh, J O; Minasi, P (1985) Role of lymphocyte and antibody in the pathogenesis of immune-mediated herpetic uveitis. Curr Eye Res 4:685-91
Oh, J O; Minasi, P; Grabner, G et al. (1985) Suppression of secondary herpes simplex uveitis by cyclosporine. Invest Ophthalmol Vis Sci 26:494-500