Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY001197-13S1
Application #
3255759
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1977-01-06
Project End
1987-06-30
Budget Start
1986-01-01
Budget End
1987-06-30
Support Year
13
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Holleschau, A M; Rathbun, W B; Nagasawa, H T (1996) An HPLC radiotracer method for assessing the ability of L-cysteine prodrugs to maintain glutathione levels in the cultured rat lens. Curr Eye Res 15:501-10
Nagasawa, H T; Shoeman, D W; Cohen, J F et al. (1996) Protection against acetaminophen-induced hepatotoxicity by L-CySSME and its N-acetyl and ethyl ester derivatives. J Biochem Toxicol 11:289-95
Rathbun, W B; Holleschau, A M; Cohen, J F et al. (1996) Prevention of acetaminophen- and naphthalene-induced cataract and glutathione loss by CySSME. Invest Ophthalmol Vis Sci 37:923-9
Rathbun, W B; Nagasawa, H T; Killen, C E (1996) Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA. Exp Eye Res 62:433-41
Rathbun, W B; Killen, C E; Holleschau, A M et al. (1996) Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs. Biochem Pharmacol 51:1111-6
Rathbun, W B (1995) Influence on lenticular glutathione research. Ophthalmic Res 27 Suppl 1:13-7
Holleschau, A M; Rathbun, W B (1994) The effects of age on glutathione peroxidase and glutathione reductase activities in lenses of Old World simians and prosimians. Curr Eye Res 13:331-6
Rathbun, W B; Schmidt, A J; Holleschau, A M (1993) Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract. Invest Ophthalmol Vis Sci 34:2049-54
Rathbun, W B; Holleschau, A M (1992) The effects of age on glutathione synthesis enzymes in lenses of Old World simians and prosimians. Curr Eye Res 11:601-7
Rathbun, W B; Murray, D L (1991) Age-related cysteine uptake as rate-limiting in glutathione synthesis and glutathione half-life in the cultured human lens. Exp Eye Res 53:205-12

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