Abstract

Our purpose is to develop more effective ocular antifungal therapy by an enhanced understanding of the efficacy and pharmacokinetics of antifungal agents as they relate to the eye. Studies with susceptible and resistant strains of Candida albicans will be continued to determine whether within these groups there is true interstrain variation in response. A cooperative study between our laboratory and four other laboratories will investigate predictability and reproducibility of in vitro susceptibility testing and the correlation with in vivo response. The efficacy of imidazoles and flucytosine will be studied in an in vivo model and correlated with in vitro response. Models of Candida parapsilosis and Aspergillus fumigatus keratitis will be studied under similar conditions. Drug potentiation and interaction will be evaluated. Pharmacokinetic studies will be continued.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001621-14
Application #
3256056
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1979-04-01
Project End
1992-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
14
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203

  Publications

O'Day, D M; Head, W S (2000) Advances in the management of keratomycosis and Acanthamoeba keratitis. Cornea 19:681-7
O'Day, D M; Head, W S; Csank, C et al. (2000) Differences in virulence between two Candida albicans strains in experimental keratitis. Invest Ophthalmol Vis Sci 41:1116-21
Braun, B R; Head, W S; Wang, M X et al. (2000) Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156:31-44
Wang, M X; Shen, D J; Liu, J C et al. (2000) Recurrent fungal keratitis and endophthalmitis. Cornea 19:558-60
O'Day, D M; Head, W S; Robinson, R D et al. (1999) Contact lens-induced infection--a new model of Candida albicans keratitis. Invest Ophthalmol Vis Sci 40:1607-11
Chang, M S; Tsai, J C; Yang, R et al. (1997) Induction of rabbit cyclooxygenase 2 in the anterior uvea following glaucoma filtration surgery. Curr Eye Res 16:1147-51
Lamps, C A; Oeltmann, T N; Collins Jr, M J et al. (1995) Development of a chitin assay for the quantification of fungus. Curr Eye Res 14:637-41
Klippenstein, K; O'Day, D M; Robinson, R D et al. (1993) The qualitative evaluation of the pharmacokinetics of subconjunctivally injected antifungal agents in rabbits. Cornea 12:512-6
O'Day, D M; Head, W S; Robinson, R D et al. (1992) The evaluation of therapeutic responses in experimental keratomycosis. Curr Eye Res 11:35-44
O'Day, D M; Head, W S; Robinson, R D et al. (1992) Ocular pharmacokinetics of saperconazole in rabbits. A potential agent against keratomycoses. Arch Ophthalmol 110:550-4

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