Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001677-22
Application #
2158188
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1978-06-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Ramana, Kota V; Bhatnagar, Aruni; Srivastava, Sanjay et al. (2006) Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. J Biol Chem 281:17652-60
Pladzyk, Agnieszka; Ramana, Kota V; Ansari, Naseem H et al. (2006) Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells. Exp Eye Res 83:408-16
Pladzyk, Agnieszka; Reddy, Aramati B M; Yadav, Umesh C S et al. (2006) Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci 47:5395-403
Singh, Ranvir; White, Mark A; Ramana, Kota V et al. (2006) Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins 64:101-10
Ramana, Kota V; Willis, Monte S; White, Michael D et al. (2006) Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 114:1838-46
Srivastava, Satish K; Ramana, Kota V; Bhatnagar, Aruni (2005) Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev 26:380-92
Ramana, Kota V; Friedrich, Brian; Tammali, Ravinder et al. (2005) Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes 54:818-29
Srivastava, Seema; Tammali, Ravinder; Chandra, Deepak et al. (2005) Regulation of lens aldose reductase activity by nitric oxide. Exp Eye Res 81:664-72
Ramana, Kota V; Bhatnagar, Aruni; Srivastava, Satish K (2004) Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett 570:189-94
Ramana, Kota V; Bhatnagar, Aruni; Srivastava, Satish K (2004) Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J 18:1209-18

Showing the most recent 10 out of 75 publications