The objective of the proposed research is to apply knowledge gained from basic research to the understanding of human ocular motor disorders. Our effort will emphasize 1) quantitative measurements of ocular motor function in both human beings and monkeys, and 2) control systems analysis to intrepret our data. Our first major interest is in the role of the cerebellum in eye movement control. We will investigate in-depth carefully selected groups of patients with abnormalities of ocular fixation related to cerebellar dysfunction as well as trained monkeys with experimental lesions in the cerebellum. We will measure the function of the vestibular, pursuit, optokinetic, and saccadic systems and with the aid of computer simulations compare the effects of simulated lesions to the ocular motor behavior of our patients and experimental animals. Our investigations should 1) provide new information about the neural control and anatomic substrate for both normal and pathologic eye movements, 2) enhance topical neuro-ophthalmologic diagnosis through more precise clinico-pathological correlations, and 3) ultimately enable us to use the knowledge gained to apply optical, pharmacological and neurosurgical techniques to the treatment of the disabling visual disturbances that frequently plague patients with ocular motor disorders and cerebellar disease.
| Shaikh, Aasef G; Wong, Aaron L; Optican, Lance M et al. (2017) Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused? Cerebellum 16:158-167 |
| Shaikh, Aasef G; Zee, David S; Jinnah, H A (2015) Oscillatory head movements in cervical dystonia: Dystonia, tremor, or both? Mov Disord 30:834-42 |
| Shaikh, Aasef G; Wong, Aaron L; Zee, David S et al. (2013) Keeping your head on target. J Neurosci 33:11281-95 |
| Tian, Jing; Ying, Howard S; Zee, David S (2013) Revisiting corrective saccades: role of visual feedback. Vision Res 89:54-64 |
| Rine, Rosemarie M; Schubert, Michael C; Whitney, Susan L et al. (2013) Vestibular function assessment using the NIH Toolbox. Neurology 80:S25-31 |
| Shaikh, Aasef G; Palla, Antonella; Marti, Sarah et al. (2013) Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities. Cerebellum 12:97-107 |
| Schubert, Michael C; Migliaccio, Americo A; Ng, Tammy W C et al. (2012) The under-compensatory roll aVOR does not affect dynamic visual acuity. J Assoc Res Otolaryngol 13:517-25 |
| Jung, Brian C; Choi, Soo I; Du, Annie X et al. (2012) MRI shows a region-specific pattern of atrophy in spinocerebellar ataxia type 2. Cerebellum 11:272-9 |
| Jung, Brian C; Choi, Soo I; Du, Annie X et al. (2012) Principal component analysis of cerebellar shape on MRI separates SCA types 2 and 6 into two archetypal modes of degeneration. Cerebellum 11:887-95 |
| Shaikh, Aasef G; Zee, David S; Optican, Lance M et al. (2011) The effects of ion channel blockers validate the conductance-based model of saccadic oscillations. Ann N Y Acad Sci 1233:58-63 |
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