The object of this research is to learn more about the mechanisms underlying both normal eye movement control and human oculomotor disorders. The research strategy is to make quantitative measurements of oculomotor function in both humans and monkeys and to use systems approaches to interpret findings. The latest techniques for measuring and analyzing eye motion around all three axes and imaging the eye muscles will be used. The focus is on mechanisms that maintain oculomotor accuracy with emphasis on binocularity and compensation for translational head motion. The study of adaptive mechanisms will be emphasized--specifically the capability to maintain eye alignment around all axes (horizontal, vertical, torsion) of eye rotation during steady fixation and during head motion. The superior oblique (SO) palsy model will be used to investigate adaptation to vertical and torsional misalignment, and the results correlated with orbital MRI. The role of the cerebellum in the immediate and long-term adaptive control of these mechanisms will be explored. Parallel and complementary human and monkey experiments are proposed. These results will provide new information about adaptive control of eye alignment relative to strabismus and eye movements that compensate for head motion.
| Shaikh, Aasef G; Wong, Aaron L; Optican, Lance M et al. (2017) Impaired Motor Learning in a Disorder of the Inferior Olive: Is the Cerebellum Confused? Cerebellum 16:158-167 |
| Shaikh, Aasef G; Zee, David S; Jinnah, H A (2015) Oscillatory head movements in cervical dystonia: Dystonia, tremor, or both? Mov Disord 30:834-42 |
| Shaikh, Aasef G; Wong, Aaron L; Zee, David S et al. (2013) Keeping your head on target. J Neurosci 33:11281-95 |
| Tian, Jing; Ying, Howard S; Zee, David S (2013) Revisiting corrective saccades: role of visual feedback. Vision Res 89:54-64 |
| Rine, Rosemarie M; Schubert, Michael C; Whitney, Susan L et al. (2013) Vestibular function assessment using the NIH Toolbox. Neurology 80:S25-31 |
| Shaikh, Aasef G; Palla, Antonella; Marti, Sarah et al. (2013) Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities. Cerebellum 12:97-107 |
| Schubert, Michael C; Migliaccio, Americo A; Ng, Tammy W C et al. (2012) The under-compensatory roll aVOR does not affect dynamic visual acuity. J Assoc Res Otolaryngol 13:517-25 |
| Jung, Brian C; Choi, Soo I; Du, Annie X et al. (2012) MRI shows a region-specific pattern of atrophy in spinocerebellar ataxia type 2. Cerebellum 11:272-9 |
| Jung, Brian C; Choi, Soo I; Du, Annie X et al. (2012) Principal component analysis of cerebellar shape on MRI separates SCA types 2 and 6 into two archetypal modes of degeneration. Cerebellum 11:887-95 |
| Shaikh, Aasef G; Zee, David S; Optican, Lance M et al. (2011) The effects of ion channel blockers validate the conductance-based model of saccadic oscillations. Ann N Y Acad Sci 1233:58-63 |
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