The main objective of this proposal is to continue the study of models of the normal and abnormal visual system. We will use psychophysical and electrophysiological techniques to aid in identifying sites of adaptation and retinal disease. An approach for comparing the psychophysical and electrophysiological data will be developed, and the data will be analyzed within the context of models of the rod and cone systems. These models will be computational models that are explicit in time. They will be used to test hypotheses about sites and mechanisms of disease related sensitivity loss in diabetes and retinitis pigmentosa. We also plan to pursue our interest in S-cone pathway vulnerability. A prospective study will be designed to evaluate whether a measure of S-cone sensitivity can predict the progression of diabetic retinopathy. In addition, using a color monitor, we will develop psychophysical paradigms to test hypotheses about sites and mechanisms of foveal color vision defects found in patients with open-angle glaucoma. The data will be analyzed within the context of recent models of cone systems, models based on recent physiology.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Visual Sciences B Study Section (VISB)
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Columbia University (N.Y.)
Other Domestic Higher Education
New York
United States
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Hood, Donald C; De Moraes, Carlos Gustavo (2018) Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields. Invest Ophthalmol Vis Sci 59:788-791
Wu, Zhichao; Weng, Denis S D; Rajshekhar, Rashmi et al. (2018) Effectiveness of a Qualitative Approach Toward Evaluating OCT Imaging for Detecting Glaucomatous Damage. Transl Vis Sci Technol 7:7
De Moraes, Carlos Gustavo; Muhammad, Hassan; Kaur, Khushmit et al. (2018) Interindividual Variations in Foveal Anatomy and Artifacts Seen on Inner Retinal Probability Maps from Spectral Domain OCT Scans of the Macula. Transl Vis Sci Technol 7:4
Mavrommatis, Maria A; Wu, Zhichao; Naegele, Saskia I et al. (2018) Deep Defects Seen on Visual Fields Spatially Correspond Well to Loss of Retinal Nerve Fiber Layer Seen on Circumpapillary OCT Scans. Invest Ophthalmol Vis Sci 59:621-628
Hood, Donald C; De Moraes, Carlos G (2018) Four Questions for Every Clinician Diagnosing and Monitoring Glaucoma. J Glaucoma 27:657-664
Wu, Zhichao; Weng, Denis S D; Thenappan, Abinaya et al. (2018) Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography. Transl Vis Sci Technol 7:11
De Moraes, C Gustavo; Hood, Donald C; Thenappan, Abinaya et al. (2017) 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology 124:1449-1456
Alhadeff, Paula A; De Moraes, Carlos G; Chen, Monica et al. (2017) The Association Between Clinical Features Seen on Fundus Photographs and Glaucomatous Damage Detected on Visual Fields and Optical Coherence Tomography Scans. J Glaucoma 26:498-504
Muhammad, Hassan; Fuchs, Thomas J; De Cuir, Nicole et al. (2017) Hybrid Deep Learning on Single Wide-field Optical Coherence tomography Scans Accurately Classifies Glaucoma Suspects. J Glaucoma 26:1086-1094
Prager, Alisa J; Hood, Donald C; Liebmann, Jeffrey M et al. (2017) Association of Glaucoma-Related, Optical Coherence Tomography-Measured Macular Damage With Vision-Related Quality of Life. JAMA Ophthalmol 135:783-788

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