Abstract

The proposed project seeks to identify and to explain the features of glaucoma's optic nerve damage in experimental primate and human glaucoma. Its features will attempt to specify the types of retinal ganglion cells most likely to suffer damage early and late in the process.
This aim will direct the search for better early phychophysical testing in human glaucoma. The study of chronic glaucoma damage histologically is correlated with the clinical appearance of the damage to improve clinical appreciation of glaucoma injury. The study will improve knowledge of the pathogenetic process by which elevated intraocular pressure causes the death of retinal ganglion cells. This information is both directly and indirectly vital to appropriate therapy of glaucoma. The study will examine in detail for the first time potential causes for the increased susceptibility to glaucoma damage found in aged, myopic, and Black persons. A method will be developed further by which the absolute size of objects in the fundus of the eye can be measured objectively. This will greatly improve the estimates of glaucoma damage in clinical practice, and can in addition be of benefit in other ophthalmic conditions, particularly in the follow-up of possible malignant melanoma.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002120-13
Application #
3256523
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1977-08-01
Project End
1990-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
13
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Pitha, Ian; Oglesby, Ericka; Chow, Amanda et al. (2018) Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor ? and Experimental Glaucoma. Transl Vis Sci Technol 7:6
Kimball, Elizabeth C; Jefferys, Joan L; Pease, Mary E et al. (2018) The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model. Exp Eye Res 172:78-85
Levin, Leonard A; Crowe, Megan E; Quigley, Harry A et al. (2017) Neuroprotection for glaucoma: Requirements for clinical translation. Exp Eye Res 157:34-37
Kimball, Elizabeth C; Pease, Mary E; Steinhart, Matthew R et al. (2017) A mouse ocular explant model that enables the study of living optic nerve head events after acute and chronic intraocular pressure elevation: Focusing on retinal ganglion cell axons and mitochondria. Exp Eye Res 160:106-115
Midgett, Dan E; Pease, Mary E; Jefferys, Joan L et al. (2017) The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations. Acta Biomater 53:123-139
Nguyen, Cathy; Midgett, Dan; Kimball, Elizabeth C et al. (2017) Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera. Invest Ophthalmol Vis Sci 58:721-733
Fu, Jie; Sun, Fengying; Liu, Wenhua et al. (2016) Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. Mol Pharm 13:2987-95
Oglesby, Ericka N; Tezel, Gülgün; Cone-Kimball, Elizabeth et al. (2016) Scleral fibroblast response to experimental glaucoma in mice. Mol Vis 22:82-99
Coudrillier, Baptiste; Pijanka, Jacek; Jefferys, Joan et al. (2015) Effects of age and diabetes on scleral stiffness. J Biomech Eng 137:
Quigley, Harry A; Pitha, Ian F; Welsbie, Derek S et al. (2015) Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One 10:e0141137

Showing the most recent 10 out of 141 publications