Abstract

This grant investigates the effects on the retina, optic nerve head, and optic nerve of monkey and human eyes of experimental and chronic human glaucoma. Neuro-anatomical methods of investigating retinal ganglion cells and their axons, as well as their terminations in the lateral geniculate body, are used to detect the sequence of cell death by type caused by elevated eye pressure.
The aim i s to develop better psychophysical tests for the early diagnosis of glaucoma. Studies of changes in structure of the optic nerve head, both clinically and histopathologically are correlated with each other in order to diagnose better the physical appearances that result from the pathologic events of glaucoma. Detailed studies of the molecular structure of the supportive tissue of the optic nerve head are performed, investigating both the cause of damage to nerve fibers and the events which occur clinically that may point towards susceptibility factors causing some persons (blacks and myopes) to suffer damage from glaucoma at a greater rate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY002120-14
Application #
3256519
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1977-08-01
Project End
1995-07-31
Budget Start
1990-08-06
Budget End
1991-07-31
Support Year
14
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Pitha, Ian; Oglesby, Ericka; Chow, Amanda et al. (2018) Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor ? and Experimental Glaucoma. Transl Vis Sci Technol 7:6
Kimball, Elizabeth C; Jefferys, Joan L; Pease, Mary E et al. (2018) The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model. Exp Eye Res 172:78-85
Levin, Leonard A; Crowe, Megan E; Quigley, Harry A et al. (2017) Neuroprotection for glaucoma: Requirements for clinical translation. Exp Eye Res 157:34-37
Kimball, Elizabeth C; Pease, Mary E; Steinhart, Matthew R et al. (2017) A mouse ocular explant model that enables the study of living optic nerve head events after acute and chronic intraocular pressure elevation: Focusing on retinal ganglion cell axons and mitochondria. Exp Eye Res 160:106-115
Midgett, Dan E; Pease, Mary E; Jefferys, Joan L et al. (2017) The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations. Acta Biomater 53:123-139
Nguyen, Cathy; Midgett, Dan; Kimball, Elizabeth C et al. (2017) Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera. Invest Ophthalmol Vis Sci 58:721-733
Fu, Jie; Sun, Fengying; Liu, Wenhua et al. (2016) Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. Mol Pharm 13:2987-95
Oglesby, Ericka N; Tezel, Gülgün; Cone-Kimball, Elizabeth et al. (2016) Scleral fibroblast response to experimental glaucoma in mice. Mol Vis 22:82-99
Coudrillier, Baptiste; Pijanka, Jacek; Jefferys, Joan et al. (2015) Effects of age and diabetes on scleral stiffness. J Biomech Eng 137:
Quigley, Harry A; Pitha, Ian F; Welsbie, Derek S et al. (2015) Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS One 10:e0141137

Showing the most recent 10 out of 141 publications