Abstract

To reduce the project to a 2 year proposal, I have retained the overall theme which is to study the effect of connective tissues of the sclera and peripapillary nerve head on axonal injury and RGC death. The portions of the 5 year proposal that were eliminated were much of former Aim 2 and 3 which dealt with studies of nerve head capillary function, and the roles of endothelin and tumor necrosis factor _ in RGC injury. We expect to test the role of connective tissue alteration in the ultimate survival of RGC in chronic experimental glaucoma (former Aim 4, now Aim 3), including the effect of chemical scleral cross-linking. To complete the project in 2 years, we eliminated from the 5 year proposal Hypotheses 7, 8, 9, and 11.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002120-32
Application #
8079351
Study Section
Special Emphasis Panel (ZRG1-BDCN-F (02))
Program Officer
Agarwal, Neeraj
Project Start
1977-08-01
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
32
Fiscal Year
2010
Total Cost
$596,589
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Pitha, Ian; Oglesby, Ericka; Chow, Amanda et al. (2018) Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor ? and Experimental Glaucoma. Transl Vis Sci Technol 7:6
Kimball, Elizabeth C; Jefferys, Joan L; Pease, Mary E et al. (2018) The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model. Exp Eye Res 172:78-85
Levin, Leonard A; Crowe, Megan E; Quigley, Harry A et al. (2017) Neuroprotection for glaucoma: Requirements for clinical translation. Exp Eye Res 157:34-37
Kimball, Elizabeth C; Pease, Mary E; Steinhart, Matthew R et al. (2017) A mouse ocular explant model that enables the study of living optic nerve head events after acute and chronic intraocular pressure elevation: Focusing on retinal ganglion cell axons and mitochondria. Exp Eye Res 160:106-115
Midgett, Dan E; Pease, Mary E; Jefferys, Joan L et al. (2017) The pressure-induced deformation response of the human lamina cribrosa: Analysis of regional variations. Acta Biomater 53:123-139
Nguyen, Cathy; Midgett, Dan; Kimball, Elizabeth C et al. (2017) Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera. Invest Ophthalmol Vis Sci 58:721-733
Fu, Jie; Sun, Fengying; Liu, Wenhua et al. (2016) Subconjunctival Delivery of Dorzolamide-Loaded Poly(ether-anhydride) Microparticles Produces Sustained Lowering of Intraocular Pressure in Rabbits. Mol Pharm 13:2987-95
Oglesby, Ericka N; Tezel, Gülgün; Cone-Kimball, Elizabeth et al. (2016) Scleral fibroblast response to experimental glaucoma in mice. Mol Vis 22:82-99
Murienne, Barbara J; Jefferys, Joan L; Quigley, Harry A et al. (2015) The effects of glycosaminoglycan degradation on the mechanical behavior of the posterior porcine sclera. Acta Biomater 12:195-206
Pijanka, Jacek K; Spang, Martin T; Sorensen, Thomas et al. (2015) Depth-dependent changes in collagen organization in the human peripapillary sclera. PLoS One 10:e0118648

Showing the most recent 10 out of 141 publications