Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY002430-19
Application #
2158432
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1978-03-01
Project End
2001-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Chai, Zhifang; Goodenough, Daniel A; Paul, David L (2011) Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels. Mol Biol Cell 22:4503-12
Magnotti, Laura M; Goodenough, Daniel A; Paul, David L (2011) Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality. Glia 59:1064-74
Magnotti, Laura M; Goodenough, Daniel A; Paul, David L (2011) Functional heterotypic interactions between astrocyte and oligodendrocyte connexins. Glia 59:26-34
Hou, Jianghui; Goodenough, Daniel A (2010) Claudin-16 and claudin-19 function in the thick ascending limb. Curr Opin Nephrol Hypertens 19:483-8
Hou, Jianghui; Renigunta, Aparna; Gomes, Antonio S et al. (2009) Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci U S A 106:15350-5
Goodenough, Daniel A; Paul, David L (2009) Gap junctions. Cold Spring Harb Perspect Biol 1:a002576
Calera, Mónica R; Wang, Zhao; Sanchez-Olea, Roberto et al. (2009) Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci 50:2185-93
Himmerkus, Nina; Shan, Qixian; Goerke, Boeren et al. (2008) Salt and acid-base metabolism in claudin-16 knockdown mice: impact for the pathophysiology of FHHNC patients. Am J Physiol Renal Physiol 295:F1641-7
Hou, Jianghui; Renigunta, Aparna; Konrad, Martin et al. (2008) Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest 118:619-28
Calera, Monica R; Topley, Heather L; Liao, Yongbo et al. (2006) Connexin43 is required for production of the aqueous humor in the murine eye. J Cell Sci 119:4510-9

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