Abstract

The sites and nature of retinal adaptation will be studied in a defined microcircuit of the Xenopus retina, using intracellular and extracellular recording methods. Absolute dark thresholds, increment threshold functions and receptive field organization of the retinal neurons will be defined using various patterns of spatial and chromatic stimulation. The correlation between synaptic form and function will be sought by comparing synaptic ultrastructure of photoreceptor-bipolar contacts with the morphology of the bipolar cell and its receptive field organization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003570-06
Application #
3257926
Study Section
(VID)
Project Start
1980-04-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012

  Publications

Heidelberger, Ruth; Thoreson, Wallace B; Witkovsky, Paul (2005) Synaptic transmission at retinal ribbon synapses. Prog Retin Eye Res 24:682-720
Witkovsky, Paul; Arango-Gonzalez, Blanca; Haycock, John W et al. (2005) Rat retinal dopaminergic neurons: differential maturation of somatodendritic and axonal compartments. J Comp Neurol 481:352-62
Vigh, Jozsef; Witkovsky, Paul (2004) Neurotransmitter actions on transient amacrine and ganglion cells of the turtle retina. Vis Neurosci 21:1-11
Witkovsky, Paul (2004) Dopamine and retinal function. Doc Ophthalmol 108:17-40
Witkovsky, Paul; Veisenberger, Eleonora; Haycock, John W et al. (2004) Activity-dependent phosphorylation of tyrosine hydroxylase in dopaminergic neurons of the rat retina. J Neurosci 24:4242-9
Witkovsky, Paul; Veisenberger, Eleonora; LeSauter, Joseph et al. (2003) Cellular location and circadian rhythm of expression of the biological clock gene Period 1 in the mouse retina. J Neurosci 23:7670-6
Akopian, Abram; Witkovsky, Paul (2002) Calcium and retinal function. Mol Neurobiol 25:113-32
Gabriel, Robert; de Souza, Sunita; Ziff, Edward B et al. (2002) Association of the AMPA receptor-related postsynaptic density proteins GRIP and ABP with subsets of glutamate-sensitive neurons in the rat retina. J Comp Neurol 449:129-40
Thoreson, Wallace B; Stella Jr, Salvatore L; Bryson, Eric I et al. (2002) D2-like dopamine receptors promote interactions between calcium and chloride channels that diminish rod synaptic transfer in the salamander retina. Vis Neurosci 19:235-47
Witkovsky, P; Thoreson, W; Tranchina, D (2001) Transmission at the photoreceptor synapse. Prog Brain Res 131:145-59

Showing the most recent 10 out of 62 publications