Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003600-14
Application #
2158866
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1981-09-30
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Azuma, Mitsuyoshi; Tamada, Yoshiyuki; Kanaami, Sayaka et al. (2003) Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins. Biochem Biophys Res Commun 307:558-63
Kim, Yung Hae; Kapfer, Deborah M; Boekhorst, Jos et al. (2002) Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallin. Biochemistry 41:14076-84
Lampi, Kirsten J; Shih, Marjorie; Ueda, Yoji et al. (2002) Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci 43:216-24
Nakajima, Takeshi; Nakajima, Emi; Fukiage, Chiho et al. (2002) Differential gene expression in the lens epithelial cells from selenite injected rats. Exp Eye Res 74:231-6
Lampi, Kirsten J; Kim, Yung H; Bachinger, Hans Peter et al. (2002) Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins. Mol Vis 8:359-66
Tamada, Y; Fukiage, C; Mizutani, K et al. (2001) Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats. Curr Eye Res 22:280-5
Shih, M; David, L L; Lampi, K J et al. (2001) Proteolysis by m-calpain enhances in vitro light scattering by crystallins from human and bovine lenses. Curr Eye Res 22:458-69
Nakamura, Y; Fukiage, C; Azuma, M et al. (2001) Calpain-induced light scattering in young rat lenses is enhanced by UV-B. J Ocul Pharmacol Ther 17:47-58
Lampi, K J; Oxford, J T; Bachinger, H P et al. (2001) Deamidation of human beta B1 alters the elongated structure of the dimer. Exp Eye Res 72:279-88
Shearer, T R; Ma, H; Shih, M et al. (2000) Calpains in the lens and cataractogenesis. Methods Mol Biol 144:277-85

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