Abstract

Numerous studies have demonstrated that only a small percentage of subjects with ocular hypertension actually develop primary open-angle glaucoma. Efforts to identify specific single factors as prognostic indicators of glaucomatous visual field loss have been unrewarding. In a previous retrospective study using a system of multivariate analysis, it was possible to identify accurately those individuals who developed glaucoma among a group of subjects with ocular hypertension. The present study is designed as a prospective evaluation of this multivariate estimate of risk in a selected population of subjects with ocular hypertension. Using the above system, estimates of the probability of visual field loss will be calculated for each subject at the beginning of the study. All subjects will then be followed for five years, following which the predictive estimates of visual field loss will be evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003716-05
Application #
3258138
Study Section
(VID)
Project Start
1981-05-01
Project End
1986-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Li, Baowang; Freeman, Ralph D (2010) Neurometabolic coupling in the lateral geniculate nucleus changes with extended age. J Neurophysiol 104:414-25
Pasley, Brian N; Inglis, Ben A; Freeman, Ralph D (2007) Analysis of oxygen metabolism implies a neural origin for the negative BOLD response in human visual cortex. Neuroimage 36:269-76
Viswanathan, Ahalya; Freeman, Ralph D (2007) Neurometabolic coupling in cerebral cortex reflects synaptic more than spiking activity. Nat Neurosci 10:1308-12
Peterson, Matthew R; Li, Baowang; Freeman, Ralph D (2006) Direction selectivity of neurons in the striate cortex increases as stimulus contrast is decreased. J Neurophysiol 95:2705-12
Li, Baowang; Thompson, Jeffrey K; Duong, Thang et al. (2006) Origins of cross-orientation suppression in the visual cortex. J Neurophysiol 96:1755-64
Li, Baowang; Peterson, Matthew R; Thompson, Jeffrey K et al. (2005) Cross-orientation suppression: monoptic and dichoptic mechanisms are different. J Neurophysiol 94:1645-50
Menz, Michael D; Freeman, Ralph D (2004) Temporal dynamics of binocular disparity processing in the central visual pathway. J Neurophysiol 91:1782-93
Menz, Michael D; Freeman, Ralph D (2004) Functional connectivity of disparity-tuned neurons in the visual cortex. J Neurophysiol 91:1794-807
Menz, Michael D; Freeman, Ralph D (2003) Stereoscopic depth processing in the visual cortex: a coarse-to-fine mechanism. Nat Neurosci 6:59-65
Gros, B L; Pope, D R; Cohn, T E (1999) Noise location and the slope of the psychometric function for simple motion stimuli. J Opt Soc Am A Opt Image Sci Vis 16:718-27

Showing the most recent 10 out of 13 publications