Abstract

This project attempts to determine whether photoreceptor allografts in rd-mutant mouse retina are capable of forming anatomical and functional connections with neurons of the host retina. It will also determine whether such photoreceptor allografts trophically influence the survival and function of photoreceptors in the rd- mutant mouse retina. The experiments involve electron microscopy and single ganglion cell physiology of mouse retina. The results are relevant to the treatment of photoreceptor degenerations in man.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003854-14
Application #
2710840
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1981-08-01
Project End
2000-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Gouras, Peter; Kong, Jian; Tsang, Stephen H (2002) Retinal degeneration and RPE transplantation in Rpe65(-/-) mice. Invest Ophthalmol Vis Sci 43:3307-11
Ivert, Lena; Kjeldbye, Hild; Gouras, Peter (2002) Long-term effects of short-term retinal bleb detachments in rabbits. Graefes Arch Clin Exp Ophthalmol 240:232-7
Ekesten, B; Gouras, P; Salchow, D J (2001) Ultraviolet and middle wavelength sensitive cone responses in the electroretinogram (ERG) of normal and Rpe65 -/- mice. Vision Res 41:2425-33
Salchow, D J; Trokel, S L; Kjeldbye, H et al. (2001) Isolation of human fetal cones. Curr Eye Res 22:85-9
Lai, C C; Gouras, P; Doi, K et al. (2000) Local immunosuppression prolongs survival of RPE xenografts labeled by retroviral gene transfer. Invest Ophthalmol Vis Sci 41:3134-41
Ekesten, B; Gouras, P; Yamamoto, S (2000) Cone inputs to murine retinal ganglion cells. Vision Res 40:2573-7
Lai, C C; Gouras, P; Doi, K et al. (1999) Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein. Invest Ophthalmol Vis Sci 40:2141-6
Sheng, Y; Gouras, P; Cao, H et al. (1995) Patch transplants of human fetal retinal pigment epithelium in rabbit and monkey retina. Invest Ophthalmol Vis Sci 36:381-90
Perry, J; Du, J; Kjeldbye, H et al. (1995) The effects of bFGF on RCS rat eyes. Curr Eye Res 14:585-92
Gouras, P; Cao, H; Sheng, Y et al. (1994) Patch culturing and transfer of human fetal retinal epithelium. Graefes Arch Clin Exp Ophthalmol 232:599-607

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