Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003942-15
Application #
2158962
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1982-03-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Murthy, S N; Lomasney, J W; Mak, E C et al. (1999) Interactions of G(h)/transglutaminase with phospholipase Cdelta1 and with GTP. Proc Natl Acad Sci U S A 96:11815-9
Murthy, S N; Velasco, P T; Lorand, L (1998) Properties of purified lens transglutaminase and regulation of its transamidase/crosslinking activity by GTP. Exp Eye Res 67:273-81
Lorand, L; Stern, A M; Velasco, P T (1998) Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins. Exp Eye Res 66:531-6
Clement, S; Velasco, P T; Murthy, S N et al. (1998) The intermediate filament protein, vimentin, in the lens is a target for cross-linking by transglutaminase. J Biol Chem 273:7604-9
Parameswaran, K N; Cheng, X F; Chen, E C et al. (1997) Hydrolysis of gamma:epsilon isopeptides by cytosolic transglutaminases and by coagulation factor XIIIa. J Biol Chem 272:10311-7
Velasco, P T; Lukas, T J; Murthy, S N et al. (1997) Hierarchy of lens proteins requiring protection against heat-induced precipitation by the alpha crystallin chaperone. Exp Eye Res 65:497-505
Clement, S; Trejo-Skalli, A V; Gu, L et al. (1997) A transglutaminase-related antigen associates with keratin filaments in some mouse epidermal cells. J Invest Dermatol 109:778-82
Lorand, L (1996) Neurodegenerative diseases and transglutaminase. Proc Natl Acad Sci U S A 93:14310-3
Trejo-Skalli, A V; Velasco, P T; Murthy, S N et al. (1995) Association of a transglutaminase-related antigen with intermediate filaments. Proc Natl Acad Sci U S A 92:8940-4
Lorand, L; Velasco, P T; Murthy, S N et al. (1992) Isolation of transglutaminase-reactive sequences from complex biological systems: a prominent lysine donor sequence in bovine lens. Proc Natl Acad Sci U S A 89:11161-3

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