The prevailing view about the organization of human foveal vision is that optic blur, photoreceptor sampling, and neural blur are all matched to each other. This project will scrutinize this view with laser interferometry, wave-front sensing, and adaptive optics. These technologies when combined allow the first quantitative measures of the eye's optics, cone mosaic, and neural response in the same individuals. Moreover, the use of adaptive optics allows any visual stimulus to be imaged on the retina at higher resolution than has previously been possible. We will explore the possibility that the neural visual system is not equipped to take advantage of all of the improvement in retinal image quality afforded by adaptive optics. We will test the hypothesis that improving the eye's optics leads to a degradation of performance on certain tasks such as vernier acuity and the identification of the color of small, brief flashes of light. Images of the trichromatic cone mosaic in living human eyes will be compared with maps of the color appearance of tiny flashes that stimulate single cones. These experiments will clarify the fundamental limits on spatial and color vision.
| Song, Hongxin; Rossi, Ethan A; Stone, Edwin et al. (2018) Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging. Br J Ophthalmol 102:136-141 |
| Schwarz, Christina; Sharma, Robin; Cheong, Soon Keen et al. (2018) Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared. Invest Ophthalmol Vis Sci 59:5973-5984 |
| Granger, Charles E; Yang, Qiang; Song, Hongxin et al. (2018) Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic. Invest Ophthalmol Vis Sci 59:5705-5716 |
| de la Barca, Juan Manuel Chao; Huang, Nuan-Ting; Jiao, Haihan et al. (2017) Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics. Metabolomics 13:22 |
| Marcos, Susana; Werner, John S; Burns, Stephen A et al. (2017) Vision science and adaptive optics, the state of the field. Vision Res 132:3-33 |
| Rossi, Ethan A; Granger, Charles E; Sharma, Robin et al. (2017) Imaging individual neurons in the retinal ganglion cell layer of the living eye. Proc Natl Acad Sci U S A 114:586-591 |
| Schwarz, Christina; Sharma, Robin; Fischer, William S et al. (2016) Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express 7:5148-5169 |
| Liu, Zhao; Ueda, Keiko; Kim, Hye Jin et al. (2015) Photobleaching and Fluorescence Recovery of RPE Bisretinoids. PLoS One 10:e0138081 |
| Masella, Benjamin D; Hunter, Jennifer J; Williams, David R (2014) New wrinkles in retinal densitometry. Invest Ophthalmol Vis Sci 55:7525-34 |
| Strazzeri, Jennifer M; Hunter, Jennifer J; Masella, Benjamin D et al. (2014) Focal damage to macaque photoreceptors produces persistent visual loss. Exp Eye Res 119:88-96 |
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