In recent years, increased attention has focused on the role of meibomian gland dysfunction in the pathogenesis of external eye disease, such as acne rosacea, seborrheic blepharitis, conjunctivitis, chalazia and contact lens wearing problems. External eye disease where meibomian gland dysfunction has been implicated are known to be significant causes of ocular morbidity in this country. We hypothesize that abnormalities of both structure and function of the meibomian glands are important in lid margin disease. We have an animal model of meibomian gland dysfunction (MGD) which will enable us to test this hypothesis over a three year period. Detailed study of this model is planned in order to determine the short-term and long-term natural history of MGD by detailed clinical examination, transilluminated biomicroscopy (assessment of meibomian gland morphology in vivo), microbiology, clinical histopathologic correlation, electron microscopy and biochemical analysis of lipid excretion. This study will be a collaborative effort involving clinical, morphologic, and biochemical techniques. Our long range goal is to study the effects of therapeutic intervention (e.g., tetracycline) on the progression of experimental MGD in order to determine the efficacy of present day therapy in the treatment of external eye disease associated with MGD.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004455-03
Application #
3258880
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1983-09-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Jester, J V; Nicolaides, N; Kiss-Palvolgyi, I et al. (1989) Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Invest Ophthalmol Vis Sci 30:936-45
Nicolaides, N; Santos, E C; Smith, R E et al. (1989) Meibomian gland dysfunction. III. Meibomian gland lipids. Invest Ophthalmol Vis Sci 30:946-51
Jester, J V; Nicolaides, N; Smith, R E (1989) Meibomian gland dysfunction. I. Keratin protein expression in normal human and rabbit meibomian glands. Invest Ophthalmol Vis Sci 30:927-35
Jester, J V; Rajagopalan, S; Rodrigues, M (1988) Meibomian gland changes in the rhino (hrrhhrrh) mouse. Invest Ophthalmol Vis Sci 29:1190-4
Robin, J B; Nobe, J R; Suarez, E et al. (1986) Meibomian gland evaluation in patients with extended wear soft contact lens deposits. CLAO J 12:95-8
Robin, J B; Jester, J V; Nobe, J et al. (1985) In vivo transillumination biomicroscopy and photography of meibomian gland dysfunction. A clinical study. Ophthalmology 92:1423-6