Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004694-15
Application #
2159124
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-10-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Shichi, Hitoshi (2004) Cataract formation and prevention. Expert Opin Investig Drugs 13:691-701
Martynkina, Larissa P; Qian, Wei; Shichi, Hitoshi (2002) Naphthoquinone cataract in mice: mitochondrial change and protection by superoxide dismutase. J Ocul Pharmacol Ther 18:231-9
Peshenko, I V; Singh, A K; Shichi, H (2001) Bovine eye 1-Cys peroxiredoxin: expression in E. coli and antioxidant properties. J Ocul Pharmacol Ther 17:93-9
Peshenko, I V; Shichi, H (2001) Oxidation of active center cysteine of bovine 1-Cys peroxiredoxin to the cysteine sulfenic acid form by peroxide and peroxynitrite. Free Radic Biol Med 31:292-303
Singh, A K; Shichi, H (2001) Peroxiredoxin in bovine ocular tissues: immunohistochemical localization and in situ hybridization. J Ocul Pharmacol Ther 17:279-86
Qian, W; Shichi, H (2001) Naphthoquinone-Induced cataract in mice: possible involvement of Ca2+ release and calpain activation. J Ocul Pharmacol Ther 17:383-92
Qian, W; Shichi, H (2000) Cataract formation by a semiquinone metabolite of acetaminophen in mice: possible involvement of Ca(2+)and calpain activation. Exp Eye Res 71:567-74
Qian, W; Shichi, H (2000) Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2. J Ocul Pharmacol Ther 16:337-44
Qian, W; Amin, R H; Shichi, H (1999) Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice. J Ocul Pharmacol Ther 15:537-45
Zhao, C; Shichi, H (1998) Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine. J Ocul Pharmacol Ther 14:345-55

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