Abstract

During the past year we have demonstrated that immune privilege within the anterior chamber of the eye is a dynamic, specific process in which both transplantation and tumor-specific cellular immune mechanisms are systemically suppressed while humoral immune functions remain intact. We refer to this process as anterior chamber-associated immune deviation (ACAID) and have shown that its induction and maintenance require a functional intact spleen. Our goals for the ongoing research include: (1) Identify and analyze the splenic cellular components that promote ACAID; (2) Determine if ACAID can be transferred with serum (blocking factors) or cells (suppressor cells); (3) Determine if ACAID-like processes can be induced by injecting allogeneic cells via other routes (e.g. intracranial, intratesticular, or i.v.); (4) Determine if ACAID can be induced by intracameral injection of allogeneic lymphoid cells; (5) Develop additional models of ACAID by employing different tumor cell lines and inbred mouse strains.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY005678-05
Application #
3261033
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1979-07-01
Project End
1990-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101

  Publications

Mo, J-S; Maier, P; Bohringer, D et al. (2012) Total protein concentration and T-cell suppression activity of aqueous humour before and after penetrating keratoplasty. Eye (Lond) 26:153-8
Sugita, Sunao; Horie, Shintaro; Nakamura, Orie et al. (2008) Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells. J Immunol 181:7525-36
Jager, M J; Gregerson, D S; Streilein, J W (1995) Regulators of immunological responses in the cornea and the anterior chamber of the eye. Eye (Lond) 9 ( Pt 2):241-6
Taylor, A W; Streilein, J W; Cousins, S W (1994) Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. Neuroimmunomodulation 1:188-94
Hudson, S J; Streilein, J W (1994) Functional cytotoxic T cells are associated with focal lesions in the brains of SJL mice with experimental herpes simplex encephalitis. J Immunol 152:5540-7
Kosiewicz, M M; Okamoto, S; Miki, S et al. (1994) Imposing deviant immunity on the presensitized state. J Immunol 153:2962-73
Taylor, A W; Streilein, J W; Cousins, S W (1994) Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol 153:1080-6
Bando, Y; Ksander, B R; Streilein, J W (1993) Incomplete activation of lymphokine-producing T cells by alloantigenic intraocular tumours in anterior chamber-associated immune deviation. Immunology 78:266-72
Miki, S; Ksander, B; Streilein, J W (1993) Complete elimination ('cure') of progressively growing intraocular tumors by local injection of tumor-specific CD8+ T lymphocytes. Invest Ophthalmol Vis Sci 34:3622-34
Sonoda, Y; Streilein, J W (1993) Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts. J Immunol 150:1727-34

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