Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY005681-03S1
Application #
3261038
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1984-05-01
Project End
1986-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
Hamilton, Paul D; Andley, Usha P (2018) In vitro interactions of histones and ?-crystallin. Biochem Biophys Rep 15:7-12
Klionsky, Daniel J (see original citation for additional authors) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
Andley, Usha P; Goldman, Joshua W (2016) Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts. Biochim Biophys Acta 1860:234-9
Makley, Leah N; McMenimen, Kathryn A; DeVree, Brian T et al. (2015) Pharmacological chaperone for ?-crystallin partially restores transparency in cataract models. Science 350:674-7
Andley, Usha P; Malone, James P; Townsend, R Reid (2014) In vivo substrates of the lens molecular chaperones ?A-crystallin and ?B-crystallin. PLoS One 9:e95507
Wignes, Jonathan A; Goldman, Joshua W; Weihl, Conrad C et al. (2013) p62 expression and autophagy in ?B-crystallin R120G mutant knock-in mouse model of hereditary cataract. Exp Eye Res 115:263-73
Andley, Usha P; Malone, James P; Hamilton, Paul D et al. (2013) Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins ?A- and ?B-crystallin. Biochemistry 52:2933-48
Andley, Usha P; Hamilton, Paul D; Ravi, Nathan et al. (2011) A knock-in mouse model for the R120G mutation of *B-crystallin recapitulates human hereditary myopathy and cataracts. PLoS One 6:e17671
Andley, Usha P; Malone, James P; Townsend, R Reid (2011) Inhibition of lens photodamage by UV-absorbing contact lenses. Invest Ophthalmol Vis Sci 52:8330-41
Andley, Usha P; Reilly, Matthew A (2010) In vivo lens deficiency of the R49C alphaA-crystallin mutant. Exp Eye Res 90:699-702

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