Abstract

An investigator seeks support for five years to examine the role of intra-areal feedback connections in rat visual cortex.
Four aims are proposed.
The first aim will examine the synaptic organization of the inhibitory circuitry of the feedforward and feedback projections.
The second aim will examine how the gain of the thalamocortical pathway might be regulated by feedback projections.
The third aim will examine anatomically whether there are direct connections between feedforward and feedback.
The final aim will examine whether the feedback projection's effectiveness is modified by use, and if this use dependence operates through an NMDA mechanism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY005935-15
Application #
6329492
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
1985-09-30
Project End
2002-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
15
Fiscal Year
2001
Total Cost
$220,175
Indirect Cost

  Institution

Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Wang, Quanxin; Burkhalter, Andreas (2013) Stream-related preferences of inputs to the superior colliculus from areas of dorsal and ventral streams of mouse visual cortex. J Neurosci 33:1696-705
Wang, Quanxin; Gao, Enquan; Burkhalter, Andreas (2007) In vivo transcranial imaging of connections in mouse visual cortex. J Neurosci Methods 159:268-76
Burkhalter, Andreas; Gonchar, Yuri; Mellor, Rebecca L et al. (2006) Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses. J Neurosci 26:12274-82
Gonchar, Y; Burkhalter, A (1997) Three distinct families of GABAergic neurons in rat visual cortex. Cereb Cortex 7:347-58
Johnson, R R; Burkhalter, A (1997) A polysynaptic feedback circuit in rat visual cortex. J Neurosci 17:7129-40
Johnson, R R; Burkhalter, A (1994) Evidence for excitatory amino acid neurotransmitters in forward and feedback corticocortical pathways within rat visual cortex. Eur J Neurosci 6:272-86
Coogan, T A; Burkhalter, A (1993) Hierarchical organization of areas in rat visual cortex. J Neurosci 13:3749-72
Burkhalter, A; Bernardo, K L; Charles, V (1993) Development of local circuits in human visual cortex. J Neurosci 13:1916-31
Jiang, X; Johnson, R R; Burkhalter, A (1993) Visualization of dendritic morphology of cortical projection neurons by retrograde axonal tracing. J Neurosci Methods 50:45-60
Johnson, R R; Burkhalter, A (1992) Evidence for excitatory amino acid neurotransmitters in the geniculo-cortical pathway and local projections within rat primary visual cortex. Exp Brain Res 89:20-30

Showing the most recent 10 out of 15 publications