Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007070-10
Application #
2161257
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Bhattacharyya, Jaya; Shipova, Ekaterina V; Santhoshkumar, Puttur et al. (2007) Effect of a single AGE modification on the structure and chaperone activity of human alphaB-crystallin. Biochemistry 46:14682-92
Cheng, Rongzhu; Feng, Qi; Argirov, Ognyan K et al. (2005) K2P--a novel cross-link from human lens protein. Ann N Y Acad Sci 1043:184-94
Cheng, Rongzhu; Lin, Bin; Ortwerth, Beryl J (2002) Rate of formation of AGEs during ascorbate glycation and during aging in human lens tissue. Biochim Biophys Acta 1587:65-74
Linetsky, M; James, H L; Ortwerth, B J (1999) Spontaneous generation of superoxide anion by human lens proteins and by calf lens proteins ascorbylated in vitro. Exp Eye Res 69:239-48
Prabhakaram, M; Ortwerth, B J (1994) Determination of glycation crosslinking by the sugar-dependent incorporation of [14C]lysine into protein. Anal Biochem 216:305-12
Nagaraj, R H; Prabhakaram, M; Ortwerth, B J et al. (1994) Suppression of pentosidine formation in galactosemic rat lens by an inhibitor of aldose reductase. Diabetes 43:580-6
Li, E Y; Feather, M S (1994) The degradation of L-threose at Maillard reaction conditions. Carbohydr Res 256:41-7
Ortwerth, B J; Speaker, J A; Prabhakaram, M et al. (1994) Ascorbic acid glycation: the reactions of L-threose in lens tissue. Exp Eye Res 58:665-74
Ortwerth, B J; Olesen, P R; Sharma, K K et al. (1993) Chemical modification of alpha crystallin. Exp Eye Res 56:107-14
Prabhakaram, M; Ortwerth, B J (1992) Glycation of MP26 and MP22 in bovine lens membranes. Biochem Biophys Res Commun 185:496-504

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