Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007099-10
Application #
2161298
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Whitson, Jeremy A; Wilmarth, Phillip A; Klimek, John et al. (2017) Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins. Free Radic Biol Med 113:84-96
Fan, Xingjun; Monnier, Vincent M; Whitson, Jeremy (2017) Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches. Exp Eye Res 156:103-111
Feng, Weiyi; Rosca, Mariana; Fan, Yuxuan et al. (2017) Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration. Hum Mol Genet 26:1376-1390
Whitson, Jeremy A; Sell, David R; Goodman, Michael C et al. (2016) Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis. Invest Ophthalmol Vis Sci 57:3914-25
Sell, David R; Sun, Wanjie; Gao, Xiaoyu et al. (2016) Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes. Cardiovasc Diabetol 15:30
Fan, Xingjun; Zhou, Sheng; Wang, Benlian et al. (2015) Evidence of Highly Conserved ?-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens. Mol Cell Proteomics 14:3211-23
Fessel, Gion; Li, Yufei; Diederich, Vincent et al. (2014) Advanced glycation end-products reduce collagen molecular sliding to affect collagen fibril damage mechanisms but not stiffness. PLoS One 9:e110948
Monnier, Vincent M; Sun, Wanjie; Sell, David R et al. (2014) Glucosepane: a poorly understood advanced glycation end product of growing importance for diabetes and its complications. Clin Chem Lab Med 52:21-32
Linetsky, Mikhail; Raghavan, Cibin T; Johar, Kaid et al. (2014) UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation. J Biol Chem 289:17111-23
Monnier, Vincent M; Sell, David R; Strauch, Christopher et al. (2013) The association between skin collagen glucosepane and past progression of microvascular and neuropathic complications in type 1 diabetes. J Diabetes Complications 27:141-9

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