Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY007566-08S1
Application #
2161578
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1988-04-01
Project End
1996-06-30
Budget Start
1995-04-01
Budget End
1996-06-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Perng, Guey-Chuen; Maguen, Barak; Jin, Ling et al. (2002) A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol 76:1224-35
Perng, Guey-Chuen; Mott, Kevin R; Osorio, Nelson et al. (2002) Herpes simplex virus type 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non-McKrae-like virulence. J Gen Virol 83:2933-42
Moxley, Michael J; Block, Timothy M; Liu, Hsi-Chou et al. (2002) Herpes simplex virus type 1 infection prevents detachment of nerve growth factor-differentiated PC12 cells in culture. J Gen Virol 83:1591-600
Samoto, Ken; Ehtesham, Moneeb; Perng, Guey-Chuen et al. (2002) A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery 50:599-605; discussion 605-6
Henderson, Gail; Peng, Weiping; Jin, Ling et al. (2002) Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript. J Neurovirol 8 Suppl 2:103-11
Perng, Guey-Chuen; Maguen, Barak; Jin, Ling et al. (2002) A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. J Virol 76:8003-10
Inman, M; Perng, G C; Henderson, G et al. (2001) Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J Virol 75:3636-46
Perng, G C; Slanina, S M; Ghiasi, H et al. (2001) The effect of latency-associated transcript on the herpes simplex virus type 1 latency-reactivation phenotype is mouse strain-dependent. J Gen Virol 82:1117-22
Perng, G C; Esmaili, D; Slanina, S M et al. (2001) Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits. J Virol 75:9018-28
Perng, G C; Jones, C; Ciacci-Zanella, J et al. (2000) Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science 287:1500-3

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