The long-term goals are to reify new, non-invasive methods for quantifying the optical quality of the eye's retinal image from wavefront measurements and determine the relationship between retinal image quality and visual performance.
The specific aims of this competitive renewal are to: 1. Test the ability of our new metrics of retinal image quality to detect change in optical disease. 2. Directly test the organizing hypothesis that a change in retinal image quality is predictive of future vision loss in optical disease. 3. Improve the power of newly developed single-valued wave aberration metrics to predict a change in visual performance by adding measurements of forward scatter. 4. Use physical and computer models to test the measurement assumptions of our new analysis of forward scatter and explore ways to improve the speed, efficiency and accuracy of our analysis.
These specific aims will be accomplished by: 1. A 5-year longitudinal study of 120 patients with cataract, monitoring visual performance and retinal image quality using metrics of aberration and scatter derived from Shack/Hartmann wavefront sensing. 2. Analyzing the data to test whether our metrics can detect change over a short time period that is predictive of future loss and in the process continually improve our metrics. 3. Building both wave aberrations and forward scatter into physical and computer models to test measurement assumptions and explore ways to improve our analysis. This line of research will advance the fundamental understanding of retinal image quality and its relation to visual performance and provide a sensitive method for assessing the optical quality of the eye and monitoring therapy designed to improve the optical quality of the eye.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008520-15
Application #
7759128
Study Section
Anterior Eye Disease Study Section (AED)
Program Officer
Wujek, Jerome R
Project Start
1991-04-01
Project End
2013-01-31
Budget Start
2010-02-01
Budget End
2013-01-31
Support Year
15
Fiscal Year
2010
Total Cost
$356,226
Indirect Cost
Name
University of Houston
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
036837920
City
Houston
State
TX
Country
United States
Zip Code
77204
Hastings, Gareth D; Marsack, Jason D; Nguyen, Lan Chi et al. (2017) Is an objective refraction optimised using the visual Strehl ratio better than a subjective refraction? Ophthalmic Physiol Opt 37:317-325
Ticak, Anita; Marsack, Jason D; Koenig, Darren E et al. (2015) A Comparison of Three Methods to Increase Scleral Contact Lens On-Eye Stability. Eye Contact Lens 41:386-90
Marsack, Jason D; Ravikumar, Ayeswarya; Nguyen, Chi et al. (2014) Wavefront-guided scleral lens correction in keratoconus. Optom Vis Sci 91:1221-30
Bradley, Arthur; Xu, Renfeng; Thibos, Larry et al. (2014) Influence of spherical aberration, stimulus spatial frequency, and pupil apodisation on subjective refractions. Ophthalmic Physiol Opt 34:309-20
Shi, Yue; Applegate, Raymond A; Wei, Xin et al. (2013) Registration tolerance of a custom correction to maintain visual acuity. Optom Vis Sci 90:1370-84
Shi, Yue; Queener, Hope M; Marsack, Jason D et al. (2013) Optimizing wavefront-guided corrections for highly aberrated eyes in the presence of registration uncertainty. J Vis 13:
Koenig, Darren E; Nguyen, Lan Chi; Parker, Katrina E et al. (2013) Factors accounting for the 4-year change in acuity in patients between 50 and 80 years. Optom Vis Sci 90:620-7
Ravikumar, Ayeswarya; Marsack, Jason D; Bedell, Harold E et al. (2013) Change in visual acuity is well correlated with change in image-quality metrics for both normal and keratoconic wavefront errors. J Vis 13:28
Ravikumar, Ayeswarya; Sarver, Edwin J; Applegate, Raymond A (2012) Change in visual acuity is highly correlated with change in six image quality metrics independent of wavefront error and/or pupil diameter. J Vis 12:11
He, Lin; Applegate, Raymond A (2011) Predicting crystalline lens fall caused by accommodation from changes in wavefront error. J Cataract Refract Surg 37:1313-22

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