Abstract

The long-term objective of this project is to understand how the properties of excitatory synapses underlie information processing in local circuits in the visual cortex. We have established techniques for recording synaptic interactions among individual cortical neurons. It is proposed to perform dual recording from specific types of synaptically connected neurons. We should study excitatory connections among pyramidal neurons and excitatory connections between pyramidal neurons and inhibitory neurons. The results of our experiments will allow us to understand both the mechanism and function of excitatory interactions in local cortical circuits. Specifically, the aims of this proposal are: 1. What are the synaptic dynamics of unitary excitatory connections during prolonged activation? 2. What is the impact of activity of a single presynaptic pyramidal cell axon on the spiking of its postsynaptic target cell?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY009120-10
Application #
2903138
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Sheridan, Philip
Project Start
1993-08-01
Project End
2003-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

Kim, Juhyun; Matney, Chanel J; Blankenship, Aaron et al. (2014) Layer 6 corticothalamic neurons activate a cortical output layer, layer 5a. J Neurosci 34:9656-64
Brown, Solange P; Hestrin, Shaul (2009) Cell-type identity: a key to unlocking the function of neocortical circuits. Curr Opin Neurobiol 19:415-21
Brown, Solange P; Hestrin, Shaul (2009) Intracortical circuits of pyramidal neurons reflect their long-range axonal targets. Nature 457:1133-6
Galarreta, Mario; Erdelyi, Ferenc; Szabo, Gabor et al. (2008) Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex. Cereb Cortex 18:2296-305
Zsiros, Veronika; Hestrin, Shaul (2005) Background synaptic conductance and precision of EPSP-spike coupling at pyramidal cells. J Neurophysiol 93:3248-56
Hestrin, Shaul; Galarreta, Mario (2005) Electrical synapses define networks of neocortical GABAergic neurons. Trends Neurosci 28:304-9
Galarreta, Mario; Erdelyi, Ferenc; Szabo, Gabor et al. (2004) Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. J Neurosci 24:9770-8
Chu, Zhiguo; Galarreta, Mario; Hestrin, Shaul (2003) Synaptic interactions of late-spiking neocortical neurons in layer 1. J Neurosci 23:96-102
Galarreta, M; Hestrin, S (2001) Spike transmission and synchrony detection in networks of GABAergic interneurons. Science 292:2295-9
Galarreta, M; Hestrin, S (2000) Burst firing induces a rebound of synaptic strength at unitary neocortical synapses. J Neurophysiol 83:621-4

Showing the most recent 10 out of 20 publications