Abstract

The long-term objective of this project is to understand how the properties of excitatory synapses underlie information processing in local circuits in the visual cortex. We have established techniques for recording synaptic interactions among individual cortical neurons. It is proposed to perform dual recording from specific types of synaptically connected neurons. We should study excitatory connections among pyramidal neurons and excitatory connections between pyramidal neurons and inhibitory neurons. The results of our experiments will allow us to understand both the mechanism and function of excitatory interactions in local cortical circuits. Specifically, the aims of this proposal are: 1. What are the synaptic dynamics of unitary excitatory connections during prolonged activation? 2. What is the impact of activity of a single presynaptic pyramidal cell axon on the spiking of its postsynaptic target cell?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009120-14
Application #
6525091
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
1993-08-01
Project End
2004-04-30
Budget Start
2002-08-01
Budget End
2004-04-30
Support Year
14
Fiscal Year
2002
Total Cost
$171,256
Indirect Cost

  Institution

Name
Stanford University
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Kim, Juhyun; Matney, Chanel J; Blankenship, Aaron et al. (2014) Layer 6 corticothalamic neurons activate a cortical output layer, layer 5a. J Neurosci 34:9656-64
Brown, Solange P; Hestrin, Shaul (2009) Cell-type identity: a key to unlocking the function of neocortical circuits. Curr Opin Neurobiol 19:415-21
Brown, Solange P; Hestrin, Shaul (2009) Intracortical circuits of pyramidal neurons reflect their long-range axonal targets. Nature 457:1133-6
Galarreta, Mario; Erdelyi, Ferenc; Szabo, Gabor et al. (2008) Cannabinoid sensitivity and synaptic properties of 2 GABAergic networks in the neocortex. Cereb Cortex 18:2296-305
Zsiros, Veronika; Hestrin, Shaul (2005) Background synaptic conductance and precision of EPSP-spike coupling at pyramidal cells. J Neurophysiol 93:3248-56
Hestrin, Shaul; Galarreta, Mario (2005) Electrical synapses define networks of neocortical GABAergic neurons. Trends Neurosci 28:304-9
Galarreta, Mario; Erdelyi, Ferenc; Szabo, Gabor et al. (2004) Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. J Neurosci 24:9770-8
Chu, Zhiguo; Galarreta, Mario; Hestrin, Shaul (2003) Synaptic interactions of late-spiking neocortical neurons in layer 1. J Neurosci 23:96-102
Galarreta, M; Hestrin, S (2001) Spike transmission and synchrony detection in networks of GABAergic interneurons. Science 292:2295-9
Galarreta, M; Hestrin, S (2000) Burst firing induces a rebound of synaptic strength at unitary neocortical synapses. J Neurophysiol 83:621-4

Showing the most recent 10 out of 20 publications