Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010123-04
Application #
2163829
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Zhang, Ying; Fan, Jieqing; Ho, Joshua W K et al. (2016) Crim1 regulates integrin signaling in murine lens development. Development 143:356-66
Lin, Haotian; Ouyang, Hong; Zhu, Jie et al. (2016) Lens regeneration using endogenous stem cells with gain of visual function. Nature 531:323-8
Li, Gen; Xu, Fan; Zhu, Jie et al. (2015) Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease. J Biol Chem 290:20448-54
Anchan, Raymond M; Lachke, Salil A; Gerami-Naini, Behzad et al. (2014) Pax6- and Six3-mediated induction of lens cell fate in mouse and human ES cells. PLoS One 9:e115106
Lachke, Salil A; Higgins, Anne W; Inagaki, Maiko et al. (2012) The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum Genet 131:235-50
Lachke, Salil A; Ho, Joshua W K; Kryukov, Gregory V et al. (2012) iSyTE: integrated Systems Tool for Eye gene discovery. Invest Ophthalmol Vis Sci 53:1617-27
Lachke, Salil A; Maas, Richard L (2011) RNA Granules and Cataract. Expert Rev Ophthalmol 6:497-500
Lachke, Salil A; Alkuraya, Fowzan S; Kneeland, Stephen C et al. (2011) Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science 331:1571-6
Lachke, Salil A; Maas, Richard L (2010) Building the developmental oculome: systems biology in vertebrate eye development and disease. Wiley Interdiscip Rev Syst Biol Med 2:305-323
Rowan, Sheldon; Siggers, Trevor; Lachke, Salil A et al. (2010) Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev 24:980-5

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