Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010765-03
Application #
2164868
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
Cursiefen, Claus; Maruyama, Kazuichi; Bock, Felix et al. (2011) Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes. J Exp Med 208:1083-92
Bachmann, B O; Luetjen-Drecoll, E; Bock, F et al. (2009) Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation. Br J Ophthalmol 93:1075-80
Bachmann, Bjoern O; Bock, Felix; Wiegand, Stanley J et al. (2008) Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation. Arch Ophthalmol 126:71-7
Cursiefen, Claus; Chen, Lu; Saint-Geniez, Magali et al. (2006) Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A 103:11405-10
Tanaka, Kazumi; Yamagami, Satoru; Streilein, J Wayne (2005) Evidence that T-helper type 2 cell-derived cytokines and eosinophils contribute to acute rejection of orthotopic corneal xenografts in mice. Transplantation 79:1317-23
Maruyama, Kazuichi; Ii, Masaaki; Cursiefen, Claus et al. (2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest 115:2363-72
Cursiefen, Claus; Ikeda, Sakae; Nishina, Patsy M et al. (2005) Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling. Am J Pathol 166:1367-77
Cursiefen, Claus; Cao, Jingtai; Chen, Lu et al. (2004) Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci 45:2666-73
Osawa, Hideya; Maruyama, Kazuichi; Streilein, J Wayne (2004) CD95 ligand expression on corneal epithelium and endothelium influences the fates of orthotopic and heterotopic corneal allografts in mice. Invest Ophthalmol Vis Sci 45:1908-15
Cursiefen, Claus; Masli, Sharmila; Ng, Tat Fong et al. (2004) Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis. Invest Ophthalmol Vis Sci 45:1117-24

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