The goal of this proposal is to investigate the role of visual area V4 in representation of and attention towards different features in the visual scene, such as contour, color/brightness, and depth, features that ultimately lead to processing and recognition of form. While in other early visual areas such as area V2, these features are represented in distinct organizations. However, due to the complexity of this area, the functional organization of area V4 has been elusive. To provide a better understanding of the functional architecture underlying form recognition and visual attention, we propose to use optical imaging, voltage sensitive dye imaging, single unit recording, and anatomical tracing methods. These experiments will elucidate the neural circuitries underlying visual behavior and attention, understanding that will have clinical relevance for, for example, attention deficit disorder and epilepsy.

Public Health Relevance

The goal of this proposal is to investigate the functional organization of visual area V4 in the primate cerebral cortex. This is an area involved in form perception and visual attention. We will study how the organization of area V4 relates to form perception and attention. Organizations underlying spatial and featural attention will be examined. These studies will elucidate the neural circuitries underlying visual behavior and attention, understanding that will have clinical relevance for conditions such as cortical strokes, attention deficit disorder, and schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY011744-10
Application #
7858052
Study Section
Central Visual Processing Study Section (CVP)
Program Officer
Steinmetz, Michael A
Project Start
1997-03-01
Project End
2012-06-30
Budget Start
2010-07-01
Budget End
2012-06-30
Support Year
10
Fiscal Year
2010
Total Cost
$352,082
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Lu, Haidong D; Chen, Gang; Cai, Junjie et al. (2017) Intrinsic signal optical imaging of visual brain activity: Tracking of fast cortical dynamics. Neuroimage 148:160-168
Chen, Gang; Lu, Haidong D; Tanigawa, Hisashi et al. (2017) Solving visual correspondence between the two eyes via domain-based population encoding in nonhuman primates. Proc Natl Acad Sci U S A 114:13024-13029
Chen, Ming; Li, Peichao; Zhu, Shude et al. (2016) An Orientation Map for Motion Boundaries in Macaque V2. Cereb Cortex 26:279-287
Roe, Anna W; Ts'o, Daniel Y (2015) Specificity of V1-V2 orientation networks in the primate visual cortex. Cortex 72:168-178
Kaas, Jon H; Roe, Anna W; Baldwin, Mary K L et al. (2015) Resolving the organization of the territory of the third visual area: a new proposal. Vis Neurosci 32:E016
Rasch, Malte J; Chen, Ming; Wu, Si et al. (2013) Quantitative inference of population response properties across eccentricity from motion-induced maps in macaque V1. J Neurophysiol 109:1233-49
Chen, Gang; Wang, Feng; Gore, John C et al. (2013) Layer-specific BOLD activation in awake monkey V1 revealed by ultra-high spatial resolution functional magnetic resonance imaging. Neuroimage 64:147-55
Wang, Zheng; Roe, Anna W (2012) Columnar specificity of microvascular oxygenation and blood flow response in primary visual cortex: evaluation by local field potential and spiking activity. J Cereb Blood Flow Metab 32:6-16
Fan, Reuben H; Baldwin, Mary K L; Jermakowicz, Walter J et al. (2012) Intrinsic signal optical imaging evidence for dorsal V3 in the prosimian galago (Otolemur garnettii). J Comp Neurol 520:4254-74
Chen, Gang; Wang, Feng; Dillenburger, Barbara C et al. (2012) Functional magnetic resonance imaging of awake monkeys: some approaches for improving imaging quality. Magn Reson Imaging 30:36-47

Showing the most recent 10 out of 29 publications