Abstract

Patterning of the fly retina starts as the morphogenetic furrow sweeps through the eye imaginal disc. Successive waves of activation of the Ras pathway recruit the photoreceptors that form the ommatidia. However, the ommatidia are not all identical and later patterning events add at least two new features to the eye: one is to define the type of inner photoreceptors that are involved in detection of colored or polarized light. Another is to create chirality to the ommatidium that is essential for the correct projection pattern of the photoreceptors to the neural cartridges in the optic lobe. This new application offers to test the mechanisms underlying these two events and in particular the role of wnt's.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY012536-04
Application #
6518629
Study Section
Visual Sciences C Study Section (VISC)
Program Officer
Hunter, Chyren
Project Start
1999-05-01
Project End
2003-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$265,300
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Genetics
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Kumar, Sudha R; Patel, Hina; Tomlinson, Andrew (2015) Wingless mediated apoptosis: How cone cells direct the death of peripheral ommatidia in the developing Drosophila eye. Dev Biol 407:183-94
Mavromatakis, Yannis Emmanuel; Tomlinson, Andrew (2013) Switching cell fates in the developing Drosophila eye. Development 140:4353-61
Tomlinson, Andrew (2012) The origin of the Drosophila subretinal pigment layer. J Comp Neurol 520:2676-82
Mavromatakis, Yannis Emmanuel; Tomlinson, Andrew (2012) The role of the small GTPase Rap in Drosophila R7 photoreceptor specification. Proc Natl Acad Sci U S A 109:3844-9
Tomlinson, Andrew; Mavromatakis, Yannis Emmanuel; Struhl, Gary (2011) Three distinct roles for notch in Drosophila R7 photoreceptor specification. PLoS Biol 9:e1001132
Wang, Ji-Wu; Brent, Jonathan R; Tomlinson, Andrew et al. (2011) The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. J Clin Invest 121:4118-26
Sato, Atsushi; Tomlinson, Andrew (2007) Dorsal-ventral midline signaling in the developing Drosophila eye. Development 134:659-67
Katanaev, Vladimir L; Tomlinson, Andrew (2006) Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc Natl Acad Sci U S A 103:6524-9
Tomlinson, A; Struhl, G (2001) Delta/Notch and Boss/Sevenless signals act combinatorially to specify the Drosophila R7 photoreceptor. Mol Cell 7:487-95
Tomlinson, A; Struhl, G (1999) Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye. Development 126:5725-38