The mechanisms and function of spontaneous neural activity in the developing mammalian retina will be studied. Immature retinal neurons spontaneously generate correlated activity in the form of waves of action potentials that sweep across the retinal ganglion cell layer. These """"""""retinal waves"""""""" occur during the developmental period when retinal ganglion cell axons are segregating into eye-specific layers in the lateral geniculate nucleus. Experiments using a combination optical imaging, electrophysiology and modeling are proposed to investigate the mechanisms of intercellular coupling that underlie the propagation of retinal waves. In addition, pharmacological manipulations that significantly alter the correlated firing patterns induced by retinal waves and transgenic mice lacking retinal waves will be used to investigate their role in the development of retinal projections to the lateral geniculate nucleus. One result of this work will be to determine the critical parameters of the activity patterns generated by retinal waves for driving activity dependent developmental processes. This work will test the hypothesis that spontaneous, correlated activity is responsible for proper organization of synapses in the developing nervous system and will lead to a further understanding of the cellular and molecular basis for activity-dependent processes in the developing visual system. This work should further our understanding of the organizing principles that govern the normal development of the human nervous system, making it possible to understand the origin of neurological birth defects and to devise strategies that allow the nervous system to regenerate functioning neural circuits after injury.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY013528-01A1
Application #
6469916
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Hunter, Chyren
Project Start
2002-04-01
Project End
2007-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
1
Fiscal Year
2002
Total Cost
$273,602
Indirect Cost
Name
University of California San Diego
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Tiriac, Alexandre; Smith, Benjamin E; Feller, Marla B (2018) Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation. Neuron 100:1059-1065.e4
Marques, Tiago; Summers, Mathew T; Fioreze, Gabriela et al. (2018) A Role for Mouse Primary Visual Cortex in Motion Perception. Curr Biol 28:1703-1713.e6
Morrie, Ryan D; Feller, Marla B (2018) A Dense Starburst Plexus Is Critical for Generating Direction Selectivity. Curr Biol 28:1204-1212.e5
Arroyo, David A; Feller, Marla B (2016) Spatiotemporal Features of Retinal Waves Instruct the Wiring of the Visual Circuitry. Front Neural Circuits 10:54
Bos, RĂ©mi; Gainer, Christian; Feller, Marla B (2016) Role for Visual Experience in the Development of Direction-Selective Circuits. Curr Biol 26:1367-75
Rosa, Juliana M; Morrie, Ryan D; Baertsch, Hans C et al. (2016) Contributions of Rod and Cone Pathways to Retinal Direction Selectivity Through Development. J Neurosci 36:9683-95
Vlasits, Anna L; Morrie, Ryan D; Tran-Van-Minh, Alexandra et al. (2016) A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina. Neuron 89:1317-1330
Morrie, Ryan D; Feller, Marla B (2016) Development of synaptic connectivity in the retinal direction selective circuit. Curr Opin Neurobiol 40:45-52
Arroyo, David A; Kirkby, Lowry A; Feller, Marla B (2016) Retinal Waves Modulate an Intraretinal Circuit of Intrinsically Photosensitive Retinal Ganglion Cells. J Neurosci 36:6892-905
Morrie, Ryan D; Feller, Marla B (2015) An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina. J Neurosci 35:9281-6

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