A fundamental fact of vision is that our perception of the external world is shaped by a number of behavioral and contextual factors. These factors include visual selective attention, in which sensory information is filtered in favor of items that are behaviorally and contextually relevant. In addition, it includes the modulation of visual processing during saccadic eye movements which occur several times each second. These factors are known to modulate the processing of visual information and to contribute to adaptive visually guided behavior. In the primate brain, the visual and oculomotor systems are highly interconnected, and past work has shown that movement-related signals exert robust influences on visual processing in visual cortex. The current proposal focuses on addressing key questions concerning the role of gaze control mechanisms in visual selection and visual stability, two ways in which those mechanisms clearly influence visual perception and cognition. These questions will be addressed using a broad set of innovative approaches and tools including newly developed, large-scale, high-density Neuropixels (NP) probes made specifically for use in nonhuman primates. In this first aim, we will test the role of persistent activity in the selection of visual signals and in visually guided saccades in a set of key, complementary experiments that include large-scale neurophysiological recordings with primate NP probes. Our hypothesis is that persistent activity in the frontal eye field (FEF) serves primarily to select the visual information required to guide saccadic eye movements, and that this function is mediated by dopamine D1Rs. In the second aim, we will address a major open question regarding the basis of stimulus-driven attention by testing the contribution of posterior parietal cortex (PPC) to the representation of visual salience in the brain, and to saliency-driven behavior. Experiments in this aim combine the use of reversible inactivation of PPC with large- scale neurophysiological recordings and behavior. In the third aim, we will address another major open question regarding the basis of the distortions in vision that occur during saccadic eye movements. We will leverage the use of large-scale recordings, and the use of reversible parietal inactivation to test the role of PPC in perisaccadic changes in visual processing within extrastriate visual cortex and the FEF. Overall, our focus on the influence of gaze control mechanisms on visual processing, combined with our use of state-of-the-art neurophysiological approaches and causal methods, are likely to produce results that exert a large and sustained impact on our understanding of the neural mechanisms of visual perception and cognition.

Public Health Relevance

Results from the proposed work will have major implications for the neural basis and treatment of disorders of cognition, such as attention-deficit hyperactivity disorder (ADHD) which is one of the most common mental disorders affecting children, and which also afflicts adults. Thus the proposed research on the role the primate prefrontal and parietal cortex, and prefrontal dopamine, in attention and working-memory will have clear implications for mental health.

National Institute of Health (NIH)
National Eye Institute (NEI)
Research Project (R01)
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Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
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Flanders, Martha C
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Stanford University
Schools of Medicine
United States
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Ebitz, R Becket; Albarran, Eddy; Moore, Tirin (2018) Exploration Disrupts Choice-Predictive Signals and Alters Dynamics in Prefrontal Cortex. Neuron 97:450-461.e9
Chen, Xiaomo; Zirnsak, Marc; Moore, Tirin (2018) Dissonant Representations of Visual Space in Prefrontal Cortex during Eye Movements. Cell Rep 22:2039-2052
Merrikhi, Yaser; Clark, Kelsey; Albarran, Eddy et al. (2017) Spatial working memory alters the efficacy of input to visual cortex. Nat Commun 8:15041
Mueller, Adrienne; Hong, David S; Shepard, Steven et al. (2017) Linking ADHD to the Neural Circuitry of Attention. Trends Cogn Sci 21:474-488
Ebitz, R Becket; Moore, Tirin (2017) Selective Modulation of the Pupil Light Reflex by Microstimulation of Prefrontal Cortex. J Neurosci 37:5008-5018
Sridharan, Devarajan; Steinmetz, Nicholas A; Moore, Tirin et al. (2017) Does the Superior Colliculus Control Perceptual Sensitivity or Choice Bias during Attention? Evidence from a Multialternative Decision Framework. J Neurosci 37:480-511
Hartmann, Till S; Zirnsak, Marc; Marquis, Michael et al. (2017) Two Types of Receptive Field Dynamics in Area V4 at the Time of Eye Movements? Front Syst Neurosci 11:13
Engel, Tatiana A; Steinmetz, Nicholas A; Gieselmann, Marc A et al. (2016) Selective modulation of cortical state during spatial attention. Science 354:1140-1144
Okun, Michael; Steinmetz, Nicholas; Cossell, Lee et al. (2015) Diverse coupling of neurons to populations in sensory cortex. Nature 521:511-515
Hu, Meng; Clark, Kelsey L; Gong, Xiajing et al. (2015) Copula regression analysis of simultaneously recorded frontal eye field and inferotemporal spiking activity during object-based working memory. J Neurosci 35:8745-57

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