Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM014372-27
Application #
3268642
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1986-12-01
Project End
1993-08-31
Budget Start
1993-07-01
Budget End
1993-08-31
Support Year
27
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Public Health Research Institute
Department
Type
DUNS #
City
Newark
State
NY
Country
United States
Zip Code
Jin, R; Novick, R P (2001) Role of the double-strand origin cruciform in pT181 replication. Plasmid 46:95-105
Jin, R; Fernandez-Beros, M E; Novick, R P (1997) Why is the initiation nick site of an AT-rich rolling circle plasmid at the tip of a GC-rich cruciform? EMBO J 16:4456-66
Jin, R; Zhou, X; Novick, R P (1996) The inactive pT181 initiator heterodimer, RepC/C, binds but fails to induce melting of the plasmid replication origin. J Biol Chem 271:31086-91
Rasooly, A; Projan, S J; Novick, R P (1994) Plasmids of the pT181 family show replication-specific initiator protein modification. J Bacteriol 176:2450-3
Rasooly, A; Wang, P Z; Novick, R P (1994) Replication-specific conversion of the Staphylococcus aureus pT181 initiator protein from an active homodimer to an inactive heterodimer. EMBO J 13:5245-51
Wang, P Z; Projan, S J; Henriquez, V et al. (1993) Origin recognition specificity in pT181 plasmids is determined by a functionally asymmetric palindromic DNA element. EMBO J 12:45-52
Bargonetti, J; Wang, P Z; Novick, R P (1993) Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis. EMBO J 12:3659-67
Rasooly, A; Novick, R P (1993) Replication-specific inactivation of the pT181 plasmid initiator protein. Science 262:1048-50
Projan, S J; Novick, R P (1992) cis-inhibitory elements in the pT181 replication system. Plasmid 27:81-92
Wang, P Z; Projan, S J; Henriquez, V et al. (1992) Specificity of origin recognition by replication initiator protein in plasmids of the pT181 family is determined by a six amino acid residue element. J Mol Biol 223:145-58

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