The primary goal of our research program continues to be the elucidation of the principles that govern the ways in which mucleic acids fold and interact with other molecules. We will do this by determining and analyzing the crystal structures of selected oligonucleotides and oligonucleotide/small molecule complexes. Our studies of DNA-small molecule interactions will include: 1) the determination of the structure of a complex between the drug actinomycin D and and a DNA fragment in an attempt to understand the molecular basis for its antitumor and antibiotic activities; 2) the determination of the structures of DNA fragments to which the chemotherapeutic agent mitomycin C have been bound; and 3) the determinations of structures of complexes between the chiral specific probe RuDIP and left and right handed DNA. In addition we will be studing the effects of sequence on the structure of DNA by determining the crystal structures of several selected oligonucleotides.
| Rao, Ramya R; Lawson, Catherine L (2014) Structure of catabolite activator protein with cobalt(II) and sulfate. Acta Crystallogr F Struct Biol Commun 70:560-3 |
| Carey, Jannette; Benoff, Brian; Harish, Balasubramanian et al. (2012) Environment-dependent long-range structural distortion in a temperature-sensitive point mutant. Protein Sci 21:63-74 |
| Lara-Gonzalez, Samuel; Birktoft, Jens J; Lawson, Catherine L (2010) Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain. Acta Crystallogr D Biol Crystallogr 66:806-12 |
| Hudson, Brian P; Quispe, Joel; Lara-Gonzalez, Samuel et al. (2009) Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc Natl Acad Sci U S A 106:19830-5 |
| Locasale, Jason W; Napoli, Andrew A; Chen, Shengfeng et al. (2009) Signatures of protein-DNA recognition in free DNA binding sites. J Mol Biol 386:1054-65 |
| Bella, Jordi; Liu, Jingsong; Kramer, Rachel et al. (2006) Conformational effects of Gly-X-Gly interruptions in the collagen triple helix. J Mol Biol 362:298-311 |
| Napoli, Andrew A; Lawson, Catherine L; Ebright, Richard H et al. (2006) Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J Mol Biol 357:173-83 |
| Tuske, Steven; Sarafianos, Stefan G; Wang, Xinyue et al. (2005) Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell 122:541-52 |
| Berman, Helen M; Ten Eyck, Lynn F; Goodsell, David S et al. (2005) The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A 102:45-50 |
| Lawson, Catherine L; Swigon, David; Murakami, Katsuhiko S et al. (2004) Catabolite activator protein: DNA binding and transcription activation. Curr Opin Struct Biol 14:10-20 |
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