The goal of this research is to determine the principles that underlie the interactions of key biological molecules. To do this, we will use the methods of x-ray crystallography to determine the three dimensional structures of selected systems. We are studying molecular complexes involved in the activation of transcription in E coli: DNA, the catabolite gene activator protein, and the alpha subunit of RNA polymerase. We are also studying RNA protein complexes that are involved in the influenza A infection. In addition, we are determining the structures of selected oligonucleotides in an attempt to understand the effects of sequence and environment on DNA structure.
| Rao, Ramya R; Lawson, Catherine L (2014) Structure of catabolite activator protein with cobalt(II) and sulfate. Acta Crystallogr F Struct Biol Commun 70:560-3 |
| Carey, Jannette; Benoff, Brian; Harish, Balasubramanian et al. (2012) Environment-dependent long-range structural distortion in a temperature-sensitive point mutant. Protein Sci 21:63-74 |
| Lara-Gonzalez, Samuel; Birktoft, Jens J; Lawson, Catherine L (2010) Structure of the Escherichia coli RNA polymerase alpha subunit C-terminal domain. Acta Crystallogr D Biol Crystallogr 66:806-12 |
| Hudson, Brian P; Quispe, Joel; Lara-Gonzalez, Samuel et al. (2009) Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc Natl Acad Sci U S A 106:19830-5 |
| Locasale, Jason W; Napoli, Andrew A; Chen, Shengfeng et al. (2009) Signatures of protein-DNA recognition in free DNA binding sites. J Mol Biol 386:1054-65 |
| Bella, Jordi; Liu, Jingsong; Kramer, Rachel et al. (2006) Conformational effects of Gly-X-Gly interruptions in the collagen triple helix. J Mol Biol 362:298-311 |
| Napoli, Andrew A; Lawson, Catherine L; Ebright, Richard H et al. (2006) Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J Mol Biol 357:173-83 |
| Tuske, Steven; Sarafianos, Stefan G; Wang, Xinyue et al. (2005) Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell 122:541-52 |
| Berman, Helen M; Ten Eyck, Lynn F; Goodsell, David S et al. (2005) The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A 102:45-50 |
| Lawson, Catherine L; Swigon, David; Murakami, Katsuhiko S et al. (2004) Catabolite activator protein: DNA binding and transcription activation. Curr Opin Struct Biol 14:10-20 |
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