Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM021967-22
Application #
2173852
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1978-06-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Oregon
Department
Type
Organized Research Units
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403
Baase, Walter A; Liu, Lijun; Tronrud, Dale E et al. (2010) Lessons from the lysozyme of phage T4. Protein Sci 19:631-41
Liu, Lijun; Marwitz, Adam J V; Matthews, Brian W et al. (2009) Boron mimetics: 1,2-dihydro-1,2-azaborines bind inside a nonpolar cavity of T4 lysozyme. Angew Chem Int Ed Engl 48:6817-9
Mooers, Blaine H M; Tronrud, Dale E; Matthews, Brian W (2009) Evaluation at atomic resolution of the role of strain in destabilizing the temperature-sensitive T4 lysozyme mutant Arg 96 --> His. Protein Sci 18:863-70
Liu, Lijun; Baase, Walter A; Matthews, Brian W (2009) Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. J Mol Biol 385:595-605
Liu, Lijun; Baase, Walter A; Michael, Miya M et al. (2009) Use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in T4 lysozyme. Biochemistry 48:8842-51
Matthews, Brian W; Liu, Lijun (2009) A review about nothing: are apolar cavities in proteins really empty? Protein Sci 18:494-502
Mooers, Blaine H M; Baase, Walter A; Wray, Jonathan W et al. (2009) Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme. Protein Sci 18:871-80
Liu, Lijun; Quillin, Michael L; Matthews, Brian W (2008) Use of experimental crystallographic phases to examine the hydration of polar and nonpolar cavities in T4 lysozyme. Proc Natl Acad Sci U S A 105:14406-11
Collins, Marcus D; Quillin, Michael L; Hummer, Gerhard et al. (2007) Structural rigidity of a large cavity-containing protein revealed by high-pressure crystallography. J Mol Biol 367:752-63
Quillin, Michael L; Wingfield, Paul T; Matthews, Brian W (2006) Determination of solvent content in cavities in IL-1beta using experimentally phased electron density. Proc Natl Acad Sci U S A 103:19749-53

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