Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM022201-21
Application #
2173895
Study Section
Molecular Biology Study Section (MBY)
Project Start
1978-05-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Sathyanarayana, U G; Freeman, L A; Lee, M S et al. (1999) RNA polymerase-specific nucleosome disruption by transcription in vivo. J Biol Chem 274:16431-6
Qiu, P; Kupfer, K C; Garrard, W T (1997) A method for genome comparisons and hybridization studies using known megabase-scale DNA sequences as a reference. Genomics 43:307-15
Liang, C P; Garrard, W T (1997) Template topology and transcription: chromatin templates relaxed by localized linearization are transcriptionally active in yeast. Mol Cell Biol 17:2825-34
Fishel, B R; Sperry, A O; Garrard, W T (1993) Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region. Proc Natl Acad Sci U S A 90:5623-7
Blasquez, V C; Hale, M A; Trevorrow, K W et al. (1992) Immunoglobulin kappa gene enhancers synergistically activate gene expression but independently determine chromatin structure. J Biol Chem 267:23888-93
Lee, M S; Garrard, W T (1992) Uncoupling gene activity from chromatin structure: promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome-free regions. Proc Natl Acad Sci U S A 89:9166-70
Freeman, L A; Garrard, W T (1992) DNA supercoiling in chromatin structure and gene expression. Crit Rev Eukaryot Gene Expr 2:165-209
Whitehurst, C; Henney, H R; Max, E E et al. (1992) Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer. Nucleic Acids Res 20:4929-30
Lee, M S; Garrard, W T (1991) Positive DNA supercoiling generates a chromatin conformation characteristic of highly active genes. Proc Natl Acad Sci U S A 88:9675-9
Lee, M S; Garrard, W T (1991) Transcription-induced nucleosome 'splitting': an underlying structure for DNase I sensitive chromatin. EMBO J 10:607-15

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