Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026210-17
Application #
2174648
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1986-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Howard-Till, Rachel A; Yao, Meng-Chao (2007) Tudor nuclease genes and programmed DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell 6:1795-804
Yao, Meng-Chao; Yao, Ching-Ho; Halasz, Lia M et al. (2007) Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena. J Cell Sci 120:1978-89
Tanaka, Hisashi; Cao, Yi; Bergstrom, Donald A et al. (2007) Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer. Mol Cell Biol 27:1993-2002
Howard-Till, Rachel A; Yao, Meng-Chao (2006) Induction of gene silencing by hairpin RNA expression in Tetrahymena thermophila reveals a second small RNA pathway. Mol Cell Biol 26:8731-42
Cervantes, Marcella D; Coyne, Robert S; Xi, Xiaohui et al. (2006) The condensin complex is essential for amitotic segregation of bulk chromosomes, but not nucleoli, in the ciliate Tetrahymena thermophila. Mol Cell Biol 26:4690-700
Cervantes, Marcella D; Xi, Xiaohui; Vermaak, Danielle et al. (2006) The CNA1 histone of the ciliate Tetrahymena thermophila is essential for chromosome segregation in the germline micronucleus. Mol Biol Cell 17:485-97
Chalker, Douglas L; Fuller, Patrick; Yao, Meng-Chao (2005) Communication between parental and developing genomes during tetrahymena nuclear differentiation is likely mediated by homologous RNAs. Genetics 169:149-60
Yao, Meng-Chao; Chao, Ju-Lan (2005) RNA-guided DNA deletion in Tetrahymena: an RNAi-based mechanism for programmed genome rearrangements. Annu Rev Genet 39:537-59
Wiley, Emily A; Myers, Tamara; Parker, Kathryn et al. (2005) Class I histone deacetylase Thd1p affects nuclear integrity in Tetrahymena thermophila. Eukaryot Cell 4:981-90
Yao, Meng-Chao; Fuller, Patrick; Xi, Xiaohui (2003) Programmed DNA deletion as an RNA-guided system of genome defense. Science 300:1581-4

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