Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM026796-15
Application #
2174813
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1979-07-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kaye, Nicholas M; Emmett, Kelly J; Merrick, William C et al. (2009) Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap. J Biol Chem 284:17742-50
Svitkin, Yuri V; Evdokimova, Valentina M; Brasey, Ann et al. (2009) General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J 28:58-68
Pisarev, Andrey V; Kolupaeva, Victoria G; Pisareva, Vera P et al. (2006) Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. Genes Dev 20:624-36
Robert, Francis; Gao, Hong Qing; Donia, Marwa et al. (2006) Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis. RNA 12:717-25
Robert, Francis; Kapp, Lee D; Khan, Shakila N et al. (2006) Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell 17:4632-44
Hui, Daniel J; Terenzi, Fulvia; Merrick, William C et al. (2005) Mouse p56 blocks a distinct function of eukaryotic initiation factor 3 in translation initiation. J Biol Chem 280:3433-40
Honda, Kazuhiro; Smith, Mark A; Zhu, Xiongwei et al. (2005) Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem 280:20978-86
Komar, Anton A; Gross, Stephane R; Barth-Baus, Diane et al. (2005) Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. J Biol Chem 280:15601-11
Orton, Kevin C; Ling, Jun; Waskiewicz, Andrew J et al. (2004) Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. J Biol Chem 279:38649-57
Merrick, William C (2004) Cap-dependent and cap-independent translation in eukaryotic systems. Gene 332:1-11

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