Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM027750-14S1
Application #
3274997
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1980-04-01
Project End
1995-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
14
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Govorunova, Elena G; Sineshchekov, Oleg A; Rodarte, Elsa M et al. (2017) The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity. Sci Rep 7:43358
Govorunova, Elena G; Sineshchekov, Oleg A; Li, Hai et al. (2017) Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications. Annu Rev Biochem 86:845-872
Yi, Adrian; Li, Hai; Mamaeva, Natalia et al. (2017) Structural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K. Biochemistry 56:2197-2208
Sineshchekov, Oleg A; Govorunova, Elena G; Li, Hai et al. (2017) Bacteriorhodopsin-like channelrhodopsins: Alternative mechanism for control of cation conductance. Proc Natl Acad Sci U S A 114:E9512-E9519
Yi, Adrian; Mamaeva, Natalia; Li, Hai et al. (2016) Resonance Raman Study of an Anion Channelrhodopsin: Effects of Mutations near the Retinylidene Schiff Base. Biochemistry 55:2371-80
Li, Hai; Sineshchekov, Oleg A; Wu, Gang et al. (2016) In Vitro Activity of a Purified Natural Anion Channelrhodopsin. J Biol Chem 291:25319-25325
Govorunova, Elena G; Sineshchekov, Oleg A; Spudich, John L (2016) Structurally Distinct Cation Channelrhodopsins from Cryptophyte Algae. Biophys J 110:2302-2304
Govorunova, Elena G; Cunha, Shane R; Sineshchekov, Oleg A et al. (2016) Anion channelrhodopsins for inhibitory cardiac optogenetics. Sci Rep 6:33530
Sineshchekov, Oleg A; Li, Hai; Govorunova, Elena G et al. (2016) Photochemical reaction cycle transitions during anion channelrhodopsin gating. Proc Natl Acad Sci U S A 113:E1993-2000
Govorunova, Elena G; Sineshchekov, Oleg A; Spudich, John L (2016) Proteomonas sulcata ACR1: A Fast Anion Channelrhodopsin. Photochem Photobiol 92:257-263

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