Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM029185-16S1
Application #
1106193
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1980-09-01
Project End
1999-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nyasae, Lydia K; Hubbard, Ann L; Tuma, Pamela L (2003) Transcytotic efflux from early endosomes is dependent on cholesterol and glycosphingolipids in polarized hepatic cells. Mol Biol Cell 14:2689-705
Tuma, Pamela L; Hubbard, Ann L (2003) Transcytosis: crossing cellular barriers. Physiol Rev 83:871-932
Tuma, Pamela L; Nyasae, Lydia K; Hubbard, Ann L (2002) Nonpolarized cells selectively sort apical proteins from cell surface to a novel compartment, but lack apical retention mechanisms. Mol Biol Cell 13:3400-15
Bustos, R; Kolen, E R; Braiterman, L et al. (2001) Synapsin I is expressed in epithelial cells: localization to a unique trans-Golgi compartment. J Cell Sci 114:3695-704
Tuma, P L; Nyasae, L K; Backer, J M et al. (2001) Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. J Cell Biol 154:1197-208
Tuma, P L; Finnegan, C M; Yi, J H et al. (1999) Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins. J Cell Biol 145:1089-102
Fujita, H; Tuma, P L; Finnegan, C M et al. (1998) Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane. Biochem J 329 ( Pt 3):527-38
Ihrke, G; Hubbard, A L (1995) Control of vesicle traffic in hepatocytes. Prog Liver Dis 13:63-99
Maurice, M; Schell, M J; Lardeux, B et al. (1994) Biosynthesis and intracellular transport of a bile canalicular plasma membrane protein: studies in vivo and in the perfused rat liver. Hepatology 19:648-55
Barr, V A; Hubbard, A L (1993) Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat. Gastroenterology 105:554-71

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