Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029332-23
Application #
2175467
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1980-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Cai, Sumin; Fang, Jianwen; Li, Qing-Shan et al. (2010) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension. Biochemistry 49:8434-41
Li, Qing-Shan; Cai, Sumin; Fang, Jianwen et al. (2009) Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase. Nucleosides Nucleotides Nucleic Acids 28:473-84
Cai, Sumin; Li, Qing-Shan; Fang, Jianwen et al. (2009) The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs. Nucleosides Nucleotides Nucleic Acids 28:485-503
Li, Qing-Shan; Cai, Sumin; Fang, Jianwen et al. (2008) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. Biochemistry 47:4983-91
Wnuk, Stanislaw F; Sacasa, Pablo R; Lewandowska, Elzbieta et al. (2008) Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5'and sulfur atoms replaced by a vinyl or halovinyl unit. Bioorg Med Chem 16:5424-33
Hu, Chen; Fang, Jianwen; Borchardt, Ronald T et al. (2008) Molecular dynamics simulations of domain motions of substrate-free S-adenosyl- L-homocysteine hydrolase in solution. Proteins 71:131-43
Cai, Sumin; Li, Qing-Shan; Borchardt, Ronald T et al. (2007) The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi. Bioorg Med Chem 15:7281-7
Li, Qing-Shan; Cai, Sumin; Borchardt, Ronald T et al. (2007) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes. Biochemistry 46:5798-809
Nowak, Ireneusz; Robins, Morris J (2007) Synthesis of 3'-deoxynucleosides with 2-oxabicyclo[3.1.0]hexane sugar moieties: addition of difluorocarbene to a 3',4'-unsaturated uridine derivative and 1,2-dihydrofurans derived from D- and L-xylose1. J Org Chem 72:3319-25
Nowak, Ireneusz; Robins, Morris J (2007) Trifluoromethylation of alkenyl bromides and iodides (including 5-iodouracils) with (CF3)2Hg and Cu (""trifluoromethylcopper""). J Org Chem 72:2678-81

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