Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029344-15
Application #
2175471
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1981-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Chemistry
Type
Other Domestic Higher Education
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Bhattacharyya, Sudeep; Stankovich, Marian T; Truhlar, Donald G et al. (2007) Combined quantum mechanical and molecular mechanical simulations of one- and two-electron reduction potentials of flavin cofactor in water, medium-chain acyl-CoA dehydrogenase, and cholesterol oxidase. J Phys Chem A 111:5729-42
Saenger, Amy K; Nguyen, Tien V; Vockley, Jerry et al. (2005) Biochemical and electrochemical characterization of two variant human short-chain acyl-CoA dehydrogenases. Biochemistry 44:16035-42
Bhattacharyya, Sudeep; Ma, Shuhua; Stankovich, Marian T et al. (2005) Potential of mean force calculation for the proton and hydride transfer reactions catalyzed by medium-chain acyl-CoA dehydrogenase: effect of mutations on enzyme catalysis. Biochemistry 44:16549-62
Saenger, Amy K; Nguyen, Tien V; Vockley, Jerry et al. (2005) Thermodynamic regulation of human short-chain acyl-CoA dehydrogenase by substrate and product binding. Biochemistry 44:16043-53
Zlateva, Theodora; Quaroni, Luca; Que, Lawrence et al. (2004) Redox studies of subunit interactivity in aerobic ribonucleotide reductase from Escherichia coli. J Biol Chem 279:18742-7
Lamm, Teresa R; Kohls, Theresa D; Saenger, Amy K et al. (2003) Comparison of ligand polarization and enzyme activation in medium- and short-chain acyl-coenzyme A dehydrogenase-novel analog complexes. Arch Biochem Biophys 409:251-61
Wu, Jiaquan; Bell, Alasdair F; Luo, Lian et al. (2003) Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy. Biochemistry 42:11846-56
Lamm, Teresa R; Kohls, Theresa D; Stankovich, Marian T (2002) Activation of substrate/product couples by medium-chain acyl-CoA dehydrogenase. Arch Biochem Biophys 404:136-46
Pellett, J D; Becker, D F; Saenger, A K et al. (2001) Role of aromatic stacking interactions in the modulation of the two-electron reduction potentials of flavin and substrate/product in Megasphaera elsdenii short-chain acyl-coenzyme A dehydrogenase. Biochemistry 40:7720-8
Pellett, J D; Sabaj, K M; Stephens, A W et al. (2000) Medium-chain acyl-coenzyme A dehydrogenase bound to a product analogue, hexadienoyl-coenzyme A: effects on reduction potential, pK(a), and polarization. Biochemistry 39:13982-92

Showing the most recent 10 out of 45 publications