Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM029832-16
Application #
3277525
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1982-07-01
Project End
1995-06-30
Budget Start
1992-01-01
Budget End
1992-06-30
Support Year
16
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Skrajna, Aleksandra; Yang, Xiao-Cui; Dadlez, Michal et al. (2018) Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Nucleic Acids Res 46:4752-4770
Borchardt, Erin K; Meganck, Rita M; Vincent, Heather A et al. (2017) Inducing circular RNA formation using the CRISPR endoribonuclease Csy4. RNA 23:619-627
Duronio, Robert J; Marzluff, William F (2017) Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body. RNA Biol 14:726-738
Skrajna, Aleksandra; Yang, Xiao-Cui; Bucholc, Katarzyna et al. (2017) U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein. RNA 23:938-951
Aik, Wei Shen; Lin, Min-Han; Tan, Dazhi et al. (2017) The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS One 12:e0186034
Marzluff, William F; Koreski, Kaitlin P (2017) Birth and Death of Histone mRNAs. Trends Genet 33:745-759
Lackey, Patrick E; Welch, Joshua D; Marzluff, William F (2016) TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA. RNA 22:1673-1688
Skrajna, Aleksandra; Yang, Xiao-Cui; Tarnowski, Krzysztof et al. (2016) Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study. J Mol Biol 428:1180-1196
Djakbarova, Umidahan; Marzluff, William F; Köseo?lu, M Murat (2016) DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phase. Cell Cycle 15:1986-96
Su, Wei; Slevin, Michael K; Marzluff, William F et al. (2016) Synthetic mRNA with Superior Properties that Mimics the Intracellular Fates of Natural Histone mRNA. Methods Mol Biol 1428:93-114

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