Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM029935-15
Application #
2175673
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1982-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Xiang, Yougui; Park, Sung-Kyun; Garrard, William T (2014) A major deletion in the V?-J? intervening region results in hyperelevated transcription of proximal V? genes and a severely restricted repertoire. J Immunol 193:3746-54
Park, Sung-Kyun; Xiang, Yougui; Feng, Xin et al. (2014) Pronounced cohabitation of active immunoglobulin genes from three different chromosomes in transcription factories during maximal antibody synthesis. Genes Dev 28:1159-64
Zhou, Xiaorong; Xiang, Yougui; Ding, Xiaoling et al. (2013) Loss of an Igýý gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation. Mol Cell Biol 33:2091-101
Xiang, Yougui; Park, Sung-Kyun; Garrard, William T (2013) Výý gene repertoire and locus contraction are specified by critical DNase I hypersensitive sites within the Výý-Jýý intervening region. J Immunol 190:1819-26
Zhou, Xiaorong; Xiang, Yougui; Ding, Xiaoling et al. (2012) A new hypersensitive site, HS10, and the enhancers, E3' and Ed, differentially regulate Ig? gene expression. J Immunol 188:2722-32
Xiang, Yougui; Zhou, Xiaorong; Hewitt, Susannah L et al. (2011) A multifunctional element in the mouse Ig? locus that specifies repertoire and Ig loci subnuclear location. J Immunol 186:5356-66
Zhou, Xiaorong; Xiang, Yougui; Garrard, William T (2010) The Ig? gene enhancers, E3' and Ed, are essential for triggering transcription. J Immunol 185:7544-52
Liu, Zhe; Ma, Zhenyi; Terada, Lance S et al. (2009) Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene. J Immunol 183:3819-30
Xiang, Yougui; Garrard, William T (2008) The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation. J Immunol 180:6725-32
Xiao, Fei; Widlak, Piotr; Garrard, William T (2007) Engineered apoptotic nucleases for chromatin research. Nucleic Acids Res 35:e93

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